The invention discloses a powdered medicine for treating oral erosion, and relates to the technical field of drugs for treating the oral erosion. The powdered medicine is prepared from the following components: pearl powder, indigo naturalis, cinnabar, borneol, borax, nystatin and composite vitamin B, wherein the pearl powder has effects of convergence and tissue regeneration promotion; the indigonaturalis and the borneol have effects of clearing away heat and toxins and cooling the blood; the cinnabar can inhibit or kill skin bacteria and parasites; the borax has effects of inhibiting bacteria, preventing putrefaction and protecting the skin mucosa; the nystatin is a polyene type broad-spectrum antimicrobial agent having an effect of inhibiting the activity of fungus; the composite vitamin B is an important assistant for body metabolism. The powdered medicine disclosed by the invention can sterilize and detoxify an anabrotic wound through the mutual synergistic effect of all the components and also repair the wound, and has the advantages of an obvious curative effect and a high effective rate.