Cefmetazole sodium proliposome preparation
一种头孢美唑钠、前体脂质的技术,应用在医药领域,能够解决稳定性差等问题,达到提高稳定性、提高治疗指数、降低药物毒性的效果
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Embodiment 1
[0034] The preparation of embodiment 1 cefmetazole sodium proliposome
[0035] Prescription: Cefmetazole Sodium 25g
[0036] Polyene Phosphatidylcholine 250g
[0037] Cholesterol 40g
[0038] Oleic acid 15g
[0040] Glycine 40g
[0041] Mannitol 40g
[0042] Preparation Process
[0043] (1) Dissolve 250g polyene phosphatidylcholine, 40g cholesterol and 15g oleic acid in 1200ml ethanol / isopropanol / ethyl ether=2:1:1 mixed solvent, mix well, remove under reduced pressure on a rotary thin film evaporator Mixing solvents to prepare a phospholipid film;
[0044] (2) Add 1000ml of pH value 5.8 phosphate buffer solution, shake, stir to make phospholipid membrane fully hydrated, high-speed homogeneous emulsification, microporous membrane filtration, make blank liposome suspension;
[0045](3) Dissolve 25g of cefmetazole sodium in 500ml of water, filter through a microporous membrane, add the filtrate to the blank ...
Embodiment 2
[0047] The preparation of embodiment 2 cefmetazole sodium proliposome
[0048] Prescription: Cefmetazole Sodium 50g
[0049] Polyene Phosphatidylcholine 350g
[0050] Cholesterol 100g
[0051] Oleic acid 25g
[0053] Glycine 60g
[0054] Mannitol 60g
[0055] Preparation Process
[0056] (1) Dissolve 350g polyene phosphatidylcholine, 100g cholesterol and 25g oleic acid in a mixed solvent of 1500ml ethanol / isopropanol / ethyl ether=2:1:1, mix well, and decompress on a rotary thin film evaporator Remove the mixed solvent to obtain a phospholipid film;
[0057] (2) Add 1000ml of acetate buffer solution with a pH value of 6.0, shake and stir to make the phospholipid film fully hydrated, high-speed homogeneous emulsification, and microporous membrane filtration to obtain a blank liposome suspension;
[0058] (3) Dissolve 50g of cefmetazole sodium in 800ml of water, filter through a microporous membrane, add the ...
Embodiment 3
[0060] The preparation of embodiment 3 cefmetazole sodium proliposome
[0061] Prescription: Cefmetazole Sodium 100g
[0062] Polyene Phosphatidylcholine 300g
[0063] Cholesterol 150g
[0064] Oleic acid 60g
[0066] Glycine 160g
[0067] Mannitol 160g
[0068] Preparation Process
[0069] (1) Dissolve 300g polyene phosphatidylcholine, 150g cholesterol and 60g oleic acid in a mixed solvent of 1500ml ethanol / isopropanol / ethyl ether=2:1:1, mix well, and decompress on a rotary thin film evaporator Remove the mixed solvent to obtain a phospholipid film;
[0070] (2) Add 1200ml of citrate buffer solution with a pH value of 6.0, shake and stir to make the phospholipid film fully hydrated, high-speed homogeneous emulsification, and microporous membrane filtration to obtain a blank liposome suspension;
[0071] (3) Dissolve 100g of cefmetazole sodium in 1500ml of water, filter through a microporous membrane, add...
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