Applications of isobavachin for preparing antineoplastic, osteoporosis and senile dementia medicament
一种肿瘤、药学的技术，应用在医药领域，能够解决非经典雌激素膜信号通路作用不清楚等问题
Inactive Publication Date: 2008-08-27
BEIJING SHENOGEN BIOMEDICAL
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Problems solved by technology
However, the role of the non-canonical estrogen membrane signaling pathway is still unclear
Method used
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Embodiment 1
[0031] Example 1 In Vitro Biological Test of Formula (I) Compound
[0032] Compound of formula (I): 2,3-dihydro-7-hydroxyl-2-(4-hydroxyphenyl)-8-(3-methyl-butyl-2-enyl)-4H-1-benzo Pyran-4-one was purchased from Shanghai Yousi Biotechnology Co., Ltd.
[0033] Test 1:
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The invention relates to the use of isobavachin in preparing drugs against tumors, osteoporosis and senile dementia, which belongs to the medical field. Isobavachin has the structural formula shown as the figure (I) and a chemical name thereof : 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-butyl-2-alkenyl)-4H-1-benzopyran-4-one. The compound, in low concentration, doesn't change the expressions of ERalpha66, ERalpha46 and ERalpha36, but in high concentration, inhibits the expressions thereof at the same time. Furthermore, the compound (I) can kill breast cancer cell line MCF7 that expresses ERalpha66, ERalpha46 and ERalpha36. The compound (I) can also be used as regulator of estrogen receptor ERalpha36 to treat diseases caused by abnormal expression of estrogen receptor ERalpha36, such as tumors, osteoporosis, asthma, heart diseases and senile dementia.
Description
technical field [0001] The invention belongs to the field of medicine and relates to the application of natural compounds in the preparation of antitumor drugs, osteoporosis and senile dementia drugs. Background technique [0002] Estrogen is a steroid hormone produced by the endocrine system, which plays an important role in the reproductive system, bone tissue, cardiovascular system, immune system and central nervous system [J Cell Sci, 2003; 116(4): 585-586]. The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis. The occurrence and development of estrogen-dependent tumors, such as breast cancer, ovarian cancer and endometrial cancer, are closely related to estrogen [J SteroidBiochem.Mol.Biol., 2002, 81(1): 1-24, J Mammary Gland Biol. Neoplasia, 1998, 3(1): 49-61, Curr. Drug Targets Immune Endocr. Metabol. Disord; 2001, 1(1): 1-12, Cancer Res., 1998, 58(23) : 5367-5373, J Psychiatry Neurosci, 2002; 27 (1): ...
Claims
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IPC IPC(8): A61K31/352A61P35/00
Inventor 李靖孟坤
Owner BEIJING SHENOGEN BIOMEDICAL
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