Preparation method of pharmaceutical composition capable of improving safety of compound folium ginkgo injection
A technology of ginkgo biloba and injection, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects
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Embodiment 1
[0026]
[0027] Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pre
Embodiment 2
[0029]
[0030] Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pre
Embodiment 3
[0032]
[0033]Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pres
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