Preparation method of pharmaceutical composition capable of improving safety of compound folium ginkgo injection

A technology of ginkgo biloba and injection, which is applied in the field of medicine, can solve the problems of solution pH drop, polysorbate 80 is prone to rancidity, and accelerates the pH value of liquid medicine, etc., and achieves high dosage, improved safety, and good safety effects

Inactive Publication Date: 2017-02-22
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new type of medicine has several benefits compared to existing drugs like tincture plasters or other similar products. It's safer because it doesn’t contain any harmful chemical ingredients such as chloroformamide or dimethyltoluium bromide. Additionally, this product can be given through different routes for easy administration without causing allergic side-effects due to its high concentration of Tween-80.

Problems solved by technology

This patents discuss various methods or techniques proposed for improving the quality control standards associated with injecting Traditional Chinese Medicine into Patients' Gastrointestinal System. These technical solutions aimed towards reducing these side effects while maintaining their beneficial properties such as improved medicating efficiency and reduced risks related to chemical exposure.

Method used

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  • Preparation method of pharmaceutical composition capable of improving safety of compound folium ginkgo injection
  • Preparation method of pharmaceutical composition capable of improving safety of compound folium ginkgo injection
  • Preparation method of pharmaceutical composition capable of improving safety of compound folium ginkgo injection

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Experimental program
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Effect test

Embodiment 1

[0026]

[0027] Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pre

Embodiment 2

[0029]

[0030] Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pre

Embodiment 3

[0032]

[0033]Preparation method: Ginkgo biloba leaves and Acanthopanax add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the containing The amount of ethanol is 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and concentrate the filtrate under reduced pressure When the relative density is about 1.15 (80°C), the medicinal liquid is used for later use; the leech is decocted twice, each time for 1 hour, and the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), and let cool , add ethanol so that the ethanol content is 65%, let it stand overnight, filter, the filtrate is concentrated under reduced pres

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Abstract

The invention discloses a preparation method of a pharmaceutical composition capable of improving the safety of a compound folium ginkgo injection. The pharmaceutical composition for injection is mainly prepared from folium ginkgo extract, radix acanthopanacis extract, leech extract and isobutyl methacrylate. The cosolvent with higher safety and a more obvious cosolvent effect is adopted to replace a cosolvent polysorbate 80 causing potential safety hazards and influencing product quality in the compound folium ginkgo injection, the safety of isobutyl methacrylate is higher than that of polysorbate 80, the dosage of isobutyl methacrylate is lower, the probability and risk of adverse drug reaction are reduced, and the safety of clinical medication is improved.

Description

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Claims

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Application Information

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Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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