Oral paclitaxel composite micelle

[0042] 1) Prescription

[0043] Paclitaxel 1g

[0044] Cyclosporine 0.1g

[0045] mPEG 1000 -POE 4000 5g

[0046] 2) Preparation steps:

[0047] a) Weigh the paclitaxel, cyclosporine and mPEG of the prescribed amount 1000 -POE 4000 , add 21mL of methanol, ultrasonic heating to dissolve;

[0048] b) Rotary evaporation at 30°C until the organic solvent is evaporated to dryness to obtain a mixed film;

[0049] c) Put the prepared mixed film in a water bath at 40°C until it becomes transparent, add ultrapure water or physiological saline, or phosphate buffer solution preheated at the same temperature, and fully hydrate to obtain a transparent drug-loaded micellar solution;

[0050] d) filtering the drug-loaded micellar solution with 0.45 μm and 0.22 μm microporous membranes in sequence;

[0051] e) Refrigerate the prepared composite micelle solution in a refrigerator at 4°C.

[0053] 1) Prescription

[0054] Paclitaxel 1g

[0055] Cyclosporin 1g

[0056] mPEG 8000 -PLGA 4000 5g

[0057] 2) Preparation steps:

[0058] a) Weigh the paclitaxel, cyclosporine and mPEG of the prescribed amount 8000 -PLGA 4000 , add 24ml of acetone, ultrasonic heating to dissolve;

[0059] b) Rotary evaporation at 40°C until the organic solvent is evaporated to dryness to obtain a mixed film;

[0060] c) Put the prepared mixed film in a water bath at 50°C until it becomes transparent, add ultrapure water or physiological saline, or phosphate buffer solution preheated at the same temperature, and fully hydrate to obtain a transparent drug-loaded micellar solution;

[0061] d) filtering the drug-loaded micellar solution with 0.45 μm and 0.22 μm microporous membranes in sequence;

[0062] e) Refrigerate the prepared composite micelle solution in a refrigerator at 4°C.

[0064] 1) Prescription

[0065] Paclitaxel 1g

[0066] Cyclosporine 0.1g

[0067] mPEG 1000 -PCL 4000 12g

[0068] 2) Preparation steps:

[0069] a) Weigh the paclitaxel, cyclosporine and mPEG of the prescribed amount 1000 -PCL 4000 , add 44mL of ethyl acetate, ultrasonic heating to dissolve;

[0070] b) Rotary evaporation at 30°C until the organic solvent is evaporated to dryness to obtain a mixed film;

[0071] c) Put the prepared mixed film in a water bath at 40°C until it becomes transparent, add ultrapure water or physiological saline, or phosphate buffer solution preheated at the same temperature, and fully hydrate to obtain a transparent drug-loaded micellar solution;

[0072] d) filtering the drug-loaded micellar solution with 0.45 μm and 0.22 μm microporous membranes in sequence;

[0073] e) Refrigerate the prepared composite micelle solution in a refrigerator at 4°C.