6 results about "Piperidine" patented technology

The invention discloses a series of 8-substitued oxoisoaporphine derivatives as well as a synthetic method and application thereof. The synthetic method comprises the following steps: (1) performing cyclization reaction on 3-chlorophthalic anhydride and phenylethylamine as raw materials twice to construct an 8-Cl-1-azabenzanthrone matrix; (2) ammonifying the 8-Cl-1-azabenzanthrone matrix to obtain 8-amino-7H-dibenzoquinoline-7-ketone; (3) reacting 8-amino-7H-dibenzoquinoline-7-ketone with an acyl chloride compound connected with piperidine to obtain corresponding target products. A study of the applicant discovers that the derivatives have very good inhibition activity on acetylcholin esterase, have relatively good potential medicinal values and are expectedly used for treating Alzheimer diseases, cerebral vascular dementia and related diseases caused by reduction of similar cholinergic neurotransmitters. The structure of the 8-substitued oxoisoaporphine derivatives is shown in a formula.

The invention discloses a preparation method for dihydrosafrole. Piperidine and propionyl chloride are used as initial raw materials, and the preparation method comprises the following steps of: 1) acylation reaction of Friedel-crafts of the piperidine: reacting the piperidine and the propionyl chloride in a solvent I under the catalytic action of a lewis acid catalyst, adding iced water after finishing the reaction, standing, separating phases, washing an organic phase in the lower layer and distilling the solvent I to obtain piperonyl ethyl ketone; and 2) reduction reaction of Wolff-Kishner-Huang-min-lon of the piperonyl ethyl ketone: refluxing the piperonyl ethyl ketone and hydrazine hydrate solution at the mass concentration of 80 to 90 percent in a solvent II for hydrazone reaction, and adding polyethyleneglycol-400 and potassium hydroxide and performing hydrazone decomposing reaction to obtain the dihydrosafrole. The method for preparing the dihydrosafrole has the characteristics of high product yield rate, mild process condition, simple operation and the like.

A composition for use as a stain blocker and a method of treating substrates therewith, said composition comprising a polymer of Formula 1 having the following repeating units in random sequence

wherein

• • R¹ is H, methyl or ethyl;
  • R² and R³ are each independently H, C₁ to about C₁₀ alkyl, —COOR⁴, CONR⁵R⁶, or —CN;
  • R⁴ is M, C₁ to about C₂₀ alkyl, or C₆ to C₁₀ aryl;
  • R⁵ and R⁶ are each independently H, C₁ to C₁₀ alkyl, C₆ to C₁₀ aryl, or R⁵ and R⁶ together with the nitrogen atom form a morpholine, pyrrolidine, or piperidine ring;
  • R⁷ is a C₄ to C₈ alkyl group; M is H, an alkali metal or alkali earth metal; h is about 10 to 100 mole %; i is 0 to about 80 mole %; j is 0 to about 60 mole %; k and n are each independently 0 to about 40 mole %; and m is 0.01 to about 0.5; provided that h+i+j+k+n equals 100, and provided that i+j+k+n is greater than zero, except when h is 100%.

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

A composition for removing mercaptan from a gas stream containing at least one acid gas in addition to a mercaptan, the composition comprising a physical and/or chemical solvent for H₂S and an inclusion compound for the mercaptan. A process of treating gas stream using the composition. The inclusion compound is selected from the group consisting of, cyclodextrin, cryptand, calixarene, cucurbituril. The chemical solvent may be monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA, diisopropylamine (DIPA), diglycolamine (DGA) and methyldiethanolamine (MDEA). Examples of useful physical solvents include cyclotetramethylene sulfone (sulfolane) and its derivatives, aliphatic acid amides, NMP (n-methylpyrrolidone), N-alkylated pyrrolidones and corresponding piperidone, methanol and mixtures of dialkethers of polyethylene glycols. The method copirses scrubbing preferably the natural gas with an aqueous solution comprising the above compounds followed by a stripping regeneration step.