The invention discloses a production method of high-strength antibacterial corrugated paper based on online monitoring. The production method of the high-strength antibacterial corrugated paper based on online monitoring comprises the following steps that step 1, core layer antibacterial paper is taken and pressed into a wave shape through hot pressing; step 2, a first auxiliary supporting layer and a second auxiliary supporting layer are taken, and the first auxiliary supporting layer and the second auxiliary supporting layer are pasted on the bottom surface and the top surface of the core layer antibacterial paper through an adhesive; step 3, a first surface paper layer and a second surface paper layer are taken; the first surface paper layer is adhered to the top surface of the second auxiliary supporting layer through an adhesive; the second surface paper layer is adhered to the bottom surface of the first auxiliary supporting layer through an adhesive; and step 4, thickness monitoring is carried out. According to the production method of the high-strength antibacterial corrugated paper based on online monitoring, the core layer antibacterial paper is arranged in the corrugated paper; on one hand, the antibacterial effect can be effectively achieved; on the other hand, a certain moisture-proof function is achieved; secondly, thickness monitoring is carried out through an online thickness monitoring device; the paperboard production performance can be effectively monitored in real time; and the weight of paperboard is effectively controlled.