4 results about "Thiophene" patented technology

A process is provided for preparing spiro-hydantoin compounds of the formula II

wherein Z is N or CR_4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A₂ is a linker, G′ is a linker; Q is a linker; and R₂, R_4a, R_4c, and R_h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

The invention discloses a preparation method for a supported Mo-based oxidation desulfurization catalyst, and belongs to the technical fields of coal processing, petroleum processing and petrochemical processing, and relates to a preparation method for a solid catalyst for oxidative removal of distillate oil and sulphide-containing thiophene aromatic heterocyclic compounds in the chemical materials. The method is characterized by: loading an organic acid on a porous carrier-supported Mo-based oxide catalyst, then drying at a temperature of 70-120 DEG C; heating to the temperature of 100-180 DEG C in the protection of inert gas, and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute; then heating to the temperature of 200-260 DEG C and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute; then heating to the temperature of 300-340 DEG C and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute to prepare the catalyst. The mixture comprising Mo<6+> and low valence state Mo<5+> is loaded on the surface of the catalyst. With the present invention, the oxidation activity and the desulfurization activity of the supported Mo-based catalyst provided by the present invention can be significantly improved, and a wide application prospect in the field of deep desulfurization is provided.

The invention provides a method for preparing 5-methylthienyl-2-thiol from levulinic acid, relating to thiophene compounds. The method comprises the following steps: adding levulinic acid into a solvent, and adding a Lawesson reagent to react; washing the product with an alkali, neutralizing 4-methoxyphenylphosphonic acid to obtain a salt, and transferring the salt into a water phase, wherein the target product 5-methylthienyl-2-thiol is retained in an organic phase and separated from the 4-methoxyphenylphosphonic acid; and carrying out reduced pressure distillation on the organic phase to obtain the 5-methylthienyl-2-thiol. The raw material reacts with the Lawesson reagent, and the 5-methylthienyl-2-thiol can be prepared by a cascade thionation-cyclization-isomerization process in one reaction procedure, so the steps are simple. The sodium carbonate or sodium bicarbonate solution is used for washing, so that the Lawesson reagent residue 4-methoxyphenylphosphonic acid can be effectively removed on the premise of not influencing the target product 5-methylthienyl-2-thiol. The obtained product has abundant reaction sites, such as aromatic thiophene rings, mercapto groups and the like, and has high plasticity.