Composition that comprises at least one oxime and its use in therapeutics

Example 1

[0029]The example was carried out on FVB mice obtained from the Charles River Laboratories (BP0109 69592 L'abresle Cedex) and on FVB KO (knock-out) mice for the genes coding for the OCT 1 and 2 that were obtained ex gratia from Dr. Cisternino, member of the Inserm U705. The KO mice strains for the receptors OCT1 and OCT2 are kept at the central breeding lab of the Pharmaceutical Department, Paris V.

[0030]The OCT of the KO mice are not expressed.

[0031]Three groups of five FVB mice and three groups of five KO mice were determined

[0032]Group 1: Control group

[0033]Group 2: At time t0, 0.47 mg / kg of paraoxon (PO) was injected subcutaneously into each mouse

[0034]Group 3: At time t0, 0.47 mg / kg of paraoxon (PO) was injected subcutaneously into each mouse, and at time t=30 minutes, 50 mg / kg of pralidoxime (PRX) methyl sulfate was injected intramuscularly into them.

[0035]The respiratory frequency was measured by full-body plethysmography using a device whose description follows.

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