Filter for Removing Substances from Blood or from Blood Derivatives, and a Method for Obtaining It

a filter and substance technology, applied in the field of filtering substances, can solve the problems of increased pressure drop across, reduced platelet adhesion phenomenon of blood filtration, and low surface tension, and achieves high leukocyte retention, low undesired release, and high platelet retention

Inactive Publication Date: 2014-02-13
GVS SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a filter that can retain both leukocytes and platelets with high efficiency, while minimizing the release of undesired substances. The method used to make the filter is environmentally friendly and cost-effective. The technical effects of this invention are improved filtration for blood purification and reduced risk of complications during blood transfusions.

Problems solved by technology

In this respect, it is known that high material surface tension reduces the platelet adhesion phenomenon during blood filtration.
In contrast, low surface tension of the filter material gives rise to a hydrophobic interaction with the filtered liquid, with a greater pressure drop across the filter (less throughput for equal pressure difference) and a lack of permeation uniformity, with relative formation of channels via preferential circuits.
This polyurethane is obtained by an addition reaction of an aliphatic diisocyanate, a polyethylene glycol and butanediol, using an excess of this latter, so that the addition reaction is stoichiometrically unbalanced.
This results in an increase in production costs and hence in the cost of the final product obtained.
Another patent text, WO2005 / 113136, describes a polyurethane material for leukocyte adsorption having a weight average molecular weight equal to or exceeding 20,000 Daltons; this prior text states that the use of a polyurethane of weight average molecular weight less than 20,000 Daltons is not adequate as this molecular weight is too low for a material which is to be used for leukodepletion.
However this coating can present either a molecular weight which may be insufficient to adequately filter the blood, or on the contrary a molecular weight which is adequate, according to that stated by the inventors, but the application of which to the non-woven fabric uses methods involving the use of chemical solvents with consequent high risks to the environment.
Hence for their implementation, these methods require means to prevent release of pollutant products into the atmosphere, these means representing a certain cost which is transferred to the finished product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0032]A dispersion of polyurethane of number average molecular weight between 12 and 18 kDa in water was used, with a polymer content of 5% by weight. This dispersion was obtained by the following process: the polyol and isocyanate components are dissolved in a ketonic solvent, then dispersed in water; the solvent is finally removed by distillation.

[0033]The polyurethane coating was applied to a non-woven fabric of PBT by immersion in the dispersion maintained at ambient temperature. Drying was carried out at 60° C. After 20 hours of drying, it was washed in osmotized water at 50° C. Subsequent drying was carried out at 60° C.

example 2

[0034]A dispersion of polyurethane of number average molecular weight between 12 and 18 kDa in water was used, obtained by diluting at ambient temperature a polyurethane dispersion in water, with a PU content of 50% by weight and with the further addition of water to attain a polymer content of 0.5% by weight.

[0035]The polyurethane was NORETHANE WB 8301 produced by the firm NOVOTEX ITALIANA SPA.

[0036]The polyurethane coating was applied to a non-woven fabric of PBT by immersion in the dispersion maintained at ambient temperature. Drying was carried out at 50° C. After 20 hours of drying, it was washed in osmotized water at 45° C. Subsequent drying was carried out at 30° C.

example 3

[0037]A dispersion of polyurethane of molecular weight between 12 and 18 kDa in water was used, with a polymer content of 5% by weight.

[0038]The polyurethane coating was applied to a non-woven fabric of PBT by immersion.

[0039]Drying was carried out at 100° C.

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PUM

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Abstract

A filter for removing substances, including leukocytes and platelets by way of non-limiting example, from whole blood or from blood derivatives, the filter includes a casing containing a layered filter element, at least one layer of this latter being coated with polyurethane; this polyurethane has a number average molecular weight between 10,000 and 20,000 Dalton. A method for forming the layered filter element for a filter such as mentioned above, in which at least one layer of this filter element is impregnated with polyurethane by immersing it in a container of a mixture in which the polyurethane is present. This mixture includes a solution in which the polyurethane is dissolved in a polar solvent such as water.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This is a continuation in part of Patent Cooperation Treaty application no. PCT / IB2011 / 001792 filed 29 Jul. 2011 which claims the benefit of priority from Italian patent application no. MI2010A001514 filed 6 Aug., 2010, all incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention relates to a filter for removing substances, in particular such as leukocytes and platelets, from blood or from blood derivatives, in accordance with the introduction to the main claim. The invention also relates to a method for forming the aforesaid filter, in accordance with the corresponding independent claim.BACKGROUND OF THE INVENTION[0003]Filtration of blood components for transfusion is a known practice usually performed on the blood withdrawn from a donor. The main purpose of this filtration or purification is to reduce as much as possible the presence of leukocytes in the transfused blood (leukodepletion) and th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M1/36B05D3/02B05D5/00B05D1/18
CPCA61M1/3633B05D5/00B05D3/0209B05D1/18B01D39/00B01D2239/0478B01D2239/065A61M1/341A61M1/3601A61M1/3615A61M1/3413A61M1/342
Inventor SCAGLIARINI, MASSIMOQUERZE, LUCA
Owner GVS SPA
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