Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis

a technology of fluid flow valve and ice-nucleating agent, which is applied in the direction of peptide sources, laboratory glassware, peptides, etc., can solve the problems of affecting the operation of fluid flow valve, affecting the efficiency of fluid flow, etc., to achieve the effect of faster ra

Active Publication Date: 2018-07-19
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present inventors have developed tiny electronic components called frostings on small plates made from water molecules. These frozen areas are used for various purposes such as heat transfer between different parts inside an enclosed space. This technology allows these minute elements to work very well even when they get too hot during operation due to their ability to absorb large amounts of moisture without losing functionality.

Problems solved by technology

Technologies described in this patented text involve creating tiny structures called lithium ion batteries (LIBs) within microdevices like those mentioned earlier. LIBS technology allows precise control over how fluorescent molecules enter into different states inside the battery cells without causing damage from excessively cold conditions. By controllably changing the orientation of certain atoms near one end of the battery cell membrane, the structure formed becomes larger and easier to break up even if some other particles get stuck around them. To achieve this, various techniques involving chemical reaction mechanisms were developed, specifically hydrogen bond donating groups, hydride transferring, atomization, fusion, etc.).

Method used

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  • Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis
  • Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis
  • Fluidic devices with freeze-thaw valves with ice-nucleating agents and related methods of operation and analysis

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Embodiment Construction

[0008]Embodiments of the invention provide microfluidic chips with one or more FTVs employing one or more ice-nucleating agents (INAs) (e.g., one or more ice-nucleating proteins “INP” and / or functional fragment thereof and / or a microorganism comprising the same), that can reliably operate to freeze at relatively high temperatures and / or at faster rates than conventional microfluidic devices with FTV systems.

[0009]Embodiments of the invention provide INAs that can reliably function in aqueous solution and do not need to be dry, thereby allowing multiple valve actuations on a respective microfluidic device.

[0010]Embodiments of the invention can employ a substrate, such as, for example, polymer, glass, silicon, metal, or other substrates suitable for a microfluidic chip with FTVs.

[0011]Embodiments of the invention are directed to fluidic analysis devices that include at least one fluid channel with at least one freeze thaw valve and at least one ice nucleating agent (INA).

[0012]The

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Abstract

Embodiments of the invention provide fluidic devices such as, but not limited to, microfluidic chips, with one or more freeze thaw valves (FTVs) employing one or more ice-nucleating agents (INAs), that can reliably operate to freeze at relatively higher temperatures and/or at faster rates than conventional microfluidic devices with FTV systems.

Description

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Claims

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Application Information

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Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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