2 results about "Active center" patented technology

The invention discloses a PVC (Polyvinyl Chloride) composite modified material and a preparation method thereof, relates to a PVC modified material and a preparation method thereof, and aims to solve the problems that a product surface is rough and lusterless as a conventional PVC modified material has a certain amount of unsaturated double bonds on a molecular chain, an active center can be formed and thus the ductility is low and a melt is easily crushed. The PVC composite modified material is prepared from the following components in parts by weight: a PVC resin, a low-temperature flexibilizer, an impact modifier, processing aids, a surfactant, a composite stabilizer, a covering agent, an initiator and a cross-linking agent. The preparation method comprises the following steps: I, weighing; II, premixing so as to obtain a premix; III, mixing at different steps so as to obtain mixtures of different steps; IV, performing final mixing so as to obtain a final mixture; and V, performing extrusion pelletizing, thereby obtaining the PVC composite modified material. The invention aims to prepare the PVC composite modified material.

The invention discloses an mTORC2 (mammalian TORC2) inhibitor. According to the application, an mTORC2 inhibitor is designed and developed on the basis of a protein region Sin1-N structure of an mTORC2 specific subunit Sin1, and the mTORC2 inhibitor specifically inhibits activation of mTORC2 and specifically inhibits phosphorylation of a downstream kinase Akt activation site Ser473; compared with the existing mTOR inhibition active center-oriented small-molecule inhibitor, the variable configuration inhibitor has the advantages of strong inhibition effect and small side effect.