The invention discloses a formula of a fluororubber-ethylene propylene rubber mixing rubber compound, which comprises the following components in parts by weight: 50-70 of ethylene propylene rubber, 30-50 of fluororubber, 8-15 of nitrile buna rubber, 2.5-10 of magnesium oxide, 5-10 of zinc oxide, 0.1-0.5 of accelerant M, 0.2-1 of stearic acid, and 0.2-1 of sulphur. The fluororubber-ethylene propylene rubber mixing rubber compound obtained according to the invention is capable of simultaneously having high medium-resistant property and low-temperature-resistant property; simultaneously, proper elasticity can also be kept.