6 results about "On cells" patented technology

The invention provides antibody arrays specific for target antigens. Methods for discovery and compositions comprising native human antibodies, arrays comprising such antibodies, immortalized B cells expressing such antibodies and non-immortalized B cell libraries comprising B cells expressing such antibodies are provided. The invention provides a method for screening monoclonal antibodies for functional effects on cell surface molecules such as receptors using antibody repertoire arrays specific for target cell surface molecules. Functional antibodies directed to a target and therapeutics derived from such antibodies are also provided. High throughput and parallel screening for potentially therapeutic antibodies are provided. Antibodies directed to functional epitope clusters corresponding to a target and vaccines and therapeutics derived from such antibodies are also provided.

The invention discloses a network-based intelligent imaging analyzer for living cell culture in a box. The network-based intelligent imaging analyzer is directly arranged in the cell culture box when used, and the intelligent degree is high. The network-based intelligent imaging analyzer comprises a worktable, a support arranged on one side of the worktable, and a microscopic imaging device composed of a microscopic light source mechanism, an L-shaped microscopic optical mechanism and a photoelectric imaging part which are arranged on one side of the top of the worktable. Images captured through the device are digitally converted and transmitted to a cloud, and the device is connected with a computer or a mobile phone through the network. The network-based intelligent imaging analyzer further comprises a carrying table used for carrying culture dishes, a carrier precision rotating table mechanism, a transverse moving mechanism and a longitudinal moving mechanism. The microscopic light source mechanism is arranged at the top end of the support and is located over the carrying table. The network-based intelligent imaging analyzer has the advantages that non-contact observational study on cell culture can be achieved, the culture dishes do not need to be taken out and placed under a microscope to be observed, and the real-time changing conditions of cell culture in the culture box can be clearly observed on the computer or the mobile phone.

The invention discloses a pharmaceutical composition for treating cerebral ischemic stroke, wherein the pharmaceutical composition comprises escin B or a sodium salt thereof, and nicotinic acid, and aweight ratio of the escin B or the sodium salt thereof to the nicotinic acid is 2-20:0.5-5. According to the present invention, the composition can reduce the neurological deficit degree and the mortality of cerebral ischemia-reperfusion injury animal models, reduce the infarct volume and the brain water content caused by cerebral ischemia, obviously increase the activity of SOD in the brain tissue of rats, reduce the generation of MDA, reduce the damage on cell membrane by free radicals, increase the activity of LDH in ischemic brain tissue, and reduce lactic acid accumulation, such that thepharmaceutical composition is the ideal drug for the treatment of cerebral ischemic stroke.

The invention shows a method for patch-clamp experiments on cells or similar structures, where at least one cell is inserted into the lumen of a capillary and is positioned inside the capillary so, that a sufficiently tight seal with a resistance exceeding 1, preferably 10 GigaOhm develops between cell membrane and inner surface of the capillary. Along its length said capillary has at least at one position a smaller inner diameter than the outer diameter of said cell. Preferably the cell is inserted and positioned in the capillary by pressure, suction, sedimentation or centrifugation of a suspension or solution containing said cell. An apparatus for performing experiments using this method is described.

A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.