3 results about "Primary alcohol" patented technology

The invention provides a phosphatidyl nanometer prodrug released by enzymatic response and a preparation method and application thereof. The phosphatidyl nanometer prodrug is formed by a hydrophilia antitumor drug containing primary alcohol and a phospholipid compound through bonding of a phosphorus oxygen bond under the catalytic action of phospholipase D. The invention further provides application of the phosphatidyl nanometer prodrug released by enzymatic response for releasing the antitumor drug to tumor tissue in a targeting mode. The hydrolysis/transesterification two-way reaction characteristic of the phospholipase D highly-expressed in tumor tissue is utilized creatively, and the amphipathicity phosphatidyl nanometer prodrug is obtained through biological catalytic synthesis of the phospholipase D in vitro; when the prodrug is accumulated to tumors in a targeting mode for responding to the phospholipase D to trigger hydrolysis, the antitumor drug is specifically released, and meanwhile the purposes of safety, stability and effective release of the targeting medicine are achieved.

The invention discloses a method for synthesizing primary alcohol, which utilizes transition metal catalysis and uses isopropanol as a hydrogen source to synthesize the primary alcohol. The reaction not only uses inexpensive and environmentally friendly isopropanol as the hydrogen source and a solvent, but also has the advantages of high yield, environmental protection, and the like, and thereforethe reaction has broad development prospects.