Piroxicam belta-cyclodextrin inclusion compound micro-pill capsules

[0042] Preparation of piroxicam β-cyclodextrin inclusion complex pellets with a molar ratio of 1∶2.7 by spray coating

[0043] (1) Dissolve 32.3g of piroxicam, 300g of β-cyclodextrin, and 32.3g of 25% ammonia water in a dissolving tank pre-added with 1800g of pure water and preheated to above 65°C, and stir fully while heating until all the materials are dissolved to Clarify and keep warm at 75-85°C for later use;

[0044](2) Spray the hot solution onto 200g pellet cores under the atomization pressure of 0.05-0.5MPa, control the airflow temperature at 80-85°C, and spray the solution at a flow rate of 30-120ml / min. After spraying, piroxicam β-cyclodextrin inclusion complex pellets were prepared.

[0046] Preparation of piroxicam β-cyclodextrin inclusion compound pellets with a molar ratio of 1∶3.2 by spray coating

[0047] (1) Dissolve 33g of piroxicam, 363g of β-cyclodextrin, and 33g of 25% ammonia water in a dissolving tank pre-added with 1900g of pure water and preheated to above 65°C, fully stir while heating until the materials are completely dissolved until clarified, Keep warm at 75-85°C for later use;

[0048] (2) Spray the hot solution onto 200g pellet cores at an atomization pressure of 0.05-0.5MPa, control the airflow temperature at 80-85°C, and spray the solution at a flow rate of 20-110ml / min. After spraying, piroxicam β-cyclodextrin inclusion complex pellets were prepared.

[0050] Preparation of piroxicam β-cyclodextrin inclusion complex pellets with a molar ratio of 1∶3.8 by spray coating

[0051] (1) Dissolve 33 g of piroxicam, 431 g of β-cyclodextrin, and 33 g of 25% ammonia water in a dissolving tank pre-added with 2000 g of pure water and preheated to above 65° C., fully stir while heating until the materials are completely dissolved until clarified, Keep warm at 75-80°C for later use;

[0052] (2) Spray the hot solution onto 200g pellet cores under the atomization pressure of 0.05-0.5MPa, control the airflow temperature at 80-85°C, and spray the solution at a flow rate of 10-100ml / min. After spraying, piroxicam β-cyclodextrin inclusion complex pellets were prepared.