Alkoxy ether dendritic hyperbranched polymer, and preparation method and application thereof

A technology of hyperbranched polymer and dendrimer, which can be used in pharmaceutical formulations, medical preparations of inactive ingredients, etc., can solve problems such as toxicity, and achieve the effects of low cost, simple and easy method, and good water solubility.

Active Publication Date: 2020-08-28
SHANGHAI UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows scientists to create special types of materials that have specific properties depending on their environment or purpose. These unique material structures are designed by combining two different parts called an agent part (a chemical compound) made up from multiple small subunits joined together through bonds like covalently bonding them into one long chain). When exposed to certain temperatures or conditions they change shape due to changes in environmental factors such as pressure or ion concentration levels. They also allow these agents to bind other substances within it without being affected by external forces. Overall this innovative design makes possible controlled release of target molecule(s), which could lead to various applications including drug delivery systems, biomedical devices, sensors, etc..

Problems solved by technology

This patented describes different ways to improve the performance of heat sensitive materials called thermally responsable dendrimer(PD). These techniques include modification methods like adding specific substituents onto their backbone, introduction of heteroatom rings within the material's core region, incorporating aliphatic hydroxylic acids along its edges, and utilizing various chemistry options during synthesis process. Additionally, some researches aiming towards improving these modifications involve designing special structures containing multiple reactive sites inside the polymers themselves.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Alkoxy ether dendritic hyperbranched polymer, and preparation method and application thereof
  • Alkoxy ether dendritic hyperbranched polymer, and preparation method and application thereof
  • Alkoxy ether dendritic hyperbranched polymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In the present embodiment, a kind of preparation method of alkoxy ether branched hyperbranched polymer, the steps are as follows:

[0039] Et-TEG-AC (500mg, 0.72mmol) was dissolved in 5mL DMSO, then hyperbranched polyethyleneimine (PEI) (30.4mg, 0.0012mmol) was weighed, and stirred at 90°C for 24h. The product was purified by dialysis, using a dialysis bag with a molecular weight cut-off of 3500, dialyzed in deionized water for four days, and then lyophilized and vacuumed to obtain 134 mg of a yellow viscous liquid product PTG1 1:1 , the yield was 25.3%. figure 1 The alkoxy ether branched hyperbranched polymer PTG1 prepared for this embodiment 1:1 of 1 H NMR spectrum.

Embodiment 2

[0041] This embodiment is basically the same as Embodiment 1, especially in that:

[0042] In the present embodiment, a kind of preparation method of alkoxy ether branched hyperbranched polymer, the steps are as follows:

[0043] Et-DEG-AC (500mg, 0.89mmol) was dissolved in 5mL DMSO, and hyperbranched polyethyleneimine (PEI) (37.2mg, 0.0015mmol) was weighed, and stirred at 90°C for 24h. The product was purified by dialysis, using a dialysis bag with a molecular weight cut-off of 3500, dialyzed in deionized water for four days, and then lyophilized and vacuumed to obtain 226 mg of a yellow viscous liquid product PDG1 1:1 , the yield was 42.1%. figure 2 The alkoxyether branched hyperbranched polymer PDG1 prepared for this embodiment 1:1 of 1 H NMR spectrum.

Embodiment 3

[0045] This embodiment is basically the same as the previous embodiment, and the special features are:

[0046] In the present embodiment, a kind of preparation method of alkoxy ether branched hyperbranched polymer, the steps are as follows:

[0047] Dissolve Et-DEG-AC (250mg, 0.45mmol), Et-TEG-AC (250mg, 0.36mmol) in 5mL DMSO, then weigh hyperbranched polyethyleneimine (PEI) (50.8mg, 0.0020mmol), Stir at 90°C for 24h. The product was purified by dialysis, using a dialysis bag with a molecular weight cut-off of 3500, dialyzed in deionized water for four days, and then obtained 198 mg of yellow viscous liquid product PDTG1 by freeze-drying and vacuumizing 3:1:1 , the yield was 35.9%. image 3 The alkoxyether branched hyperbranched polymer PDTG1 prepared for this embodiment 3:1:1 of 1 H NMR spectrum.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an alkoxy ether dendritic hyperbranched polymer, and a preparation method and application thereof. The alkoxy ether dendritic hyperbranched polymer disclosed by the invention is a temperature and pH dual-response type dendritic hyperbranched polymer. Hyperbranched polyethyleneimine is modified with alkoxy ether dendronized elements with excellent temperature-sensitive characteristics, and dendronized hyperbranched polymers with different grafting rates are prepared by changing the ratio of polyethyleneimine to alkoxy ether. The polymer prepared by the invention has excellent temperature and pH dual-response behaviors and excellent biocompatibility, can realize envelope control of guest molecules as a novel intelligent molecular container, and has potential application in the fields of drug controlled release, sensors and the like.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner SHANGHAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap