Novel benzimidazole isomer preparation and preparation method thereof

[0026] A freeze-dried powder injection containing omeprazole, which is made of the following raw materials:

[0027] Omeprazole 10g, berberine hydrochloride 10g, sodium bicarbonate 500g, magnesium hydroxide 450g, hydroxypropyl-β cyclodextrin (degree of substitution 4-5) 20g, oleic acid 200g, water for injection 950g.

[0028] The preparation method of above-mentioned freeze-dried powder injection containing omeprazole, comprises the following steps:

[0029] (1) Grind and mix the prescribed amount of omeprazole, berberine hydrochloride, and magnesium hydroxide, and set aside;

[0030] (2) Weigh the prescribed amount of sodium bicarbonate, dissolve it in water for injection, and stir to dissolve it;

[0031] (3) Add the powder of step (1) to the clarified liquid of step (2), and stir for 30 minutes to form a suspension;

[0032] (4) Add hydroxypropyl-β-cyclodextrin (substitution degree is 4-5), and slowly drop oleic acid, after the dropwise addition, stir for 20 minutes;

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[0036] A freeze-dried powder injection containing omeprazole, which is made of the following raw materials:

[0037] Omeprazole 15g, berberine hydrochloride 15g, sodium bicarbonate 600g, magnesium hydroxide 500g, hydroxypropyl-β cyclodextrin (substitution degree 4-5) 30g, oleic acid 300g, water for injection 950g.

[0038] The preparation method of above-mentioned freeze-dried powder injection containing omeprazole, comprises the following steps:

[0039] (1) Grind and mix the prescribed amount of omeprazole, berberine hydrochloride, and magnesium hydroxide, and set aside;

[0040] (2) Weigh the prescribed amount of sodium bicarbonate, dissolve it in water for injection, and stir to dissolve it;

[0041] (3) Add the powder of step (1) to the clarified liquid of step (2), and stir for 40 minutes to form a suspension;

[0042] (4) Add hydroxypropyl-β-cyclodextrin (substitution degree is 4-5), and slowly drop oleic acid, after the dropwise addition, stir for 30 minutes;

[004...

[0046] A freeze-dried powder injection containing omeprazole, which is made of the following raw materials:

[0047] Omeprazole 13g, berberine hydrochloride 12g, sodium bicarbonate 550g, magnesium hydroxide 480g, low polyester β-cyclodextrin 25g, oleic acid 210g, water for injection 950g.

[0048] The preparation method of above-mentioned freeze-dried powder injection containing omeprazole, comprises the following steps:

[0049] (1) Grind and mix the prescribed amount of omeprazole, berberine hydrochloride, and magnesium hydroxide, and set aside;

[0050] (2) Weigh the prescribed amount of sodium bicarbonate, dissolve it in water for injection, and stir to dissolve it;

[0051] (3) Add the powder of step (1) to the clarified liquid of step (2), and stir for 35 minutes to form a suspension;

[0052] (4) Add hydroxypropyl-β-cyclodextrin (substitution degree is 4-5), and slowly drop oleic acid, after the dropwise addition, stir for 25 minutes;

[0053] (5) Add 0.1mol / L sodium...