Administration method for anticancer drugs

a technology of anticancer drugs and administration methods, which is applied in the direction of medical preparations, biological testing, peptides, etc., can solve the problems of destroying cancer cells, affecting the survival rate of cancer cells, and sometimes undergoing apoptosis of cells, so as to reduce side effects of using anticancer drugs and reduce the effect of damag

Active Publication Date: 2015-10-15
DONG A UNIV RES FOUND FOR IND ACAD COOP
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  • Abstract
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AI Technical Summary

Benefits of technology

The present invention provides a method for predicting the effectiveness of chemotherapy drugs during treatment with cancer cells. By analyzing gene expressions levels associated with these treatments, we can determine which therapies should be given next based on their impact on the affected area. This helps reduce side-effects caused by other agents used in combination therapy. Additionally, this analysis allows us to identify specific genes involved in cell death and how they affect the outcome of chemotherapy. Overall, this technology improves the efficacy of chemotherapy and reduces its negative consequences.

Problems solved by technology

This patent describes various technical problem addressed in the patent text relates to improving the effectiveness of anticancer treatments in controlling tumors' growth and preventing their recurrence. Specifically, current treatments involve either targeting certain parts of the body or inducing regression of existing cancer cells. These treatments often result in severe adverse side effects such as reduced lifespan and increased risk of cancer development. Therefore, new ways to reduce the impact of the anticancer chemotherapy on normal cells without causing damage has become necessary.

Method used

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  • Administration method for anticancer drugs
  • Administration method for anticancer drugs
  • Administration method for anticancer drugs

Examples

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1. Preparation of Material and Experiments

(1) Cell Culture, Bio-Cycle Synchronization, UV Radiation and Transduction

[0134]For cell culture, 1 ml of 100 (vol / vol) fetal bovine serum (FBS, Hyclone Co.) was added to 10 ml of Dulbecco's modified Eagle's medium (DMEM), followed by adding 100 μl of 10 (vol / vol) penicillin-streptomycin thereto. Then, NIH3T3 cells, wild-type mouse embryo fibroblasts (WT MEFs), and mouse embryo fibroblasts free from cryptochrome 1 (Cry1) and cryptochrome 2(Cry2) (CryDKO MEFs), respectively, were cultured in the above prepared culture medium.

[0135]For bio-cycle synchronization, fused cells were further cultured for additional three (3) days after adding 10 mM forskolin to the above medium.

[0136]For UV radiation, using a germicidal lamp (GE) mainly emitting UV-C beam, UV light was emitted to the fused cells by 5 J / m2. Then, a fluorescence rate of the incident beam was measured using a UV-C sensor.

[0137]For transduction of DNA constructs and ON-TARGET plus S

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Abstract

Disclosed is a method for providing information used for comparing restoration rates of damaged DNA, wherein information about a time period when Ataxia telangiectasia and Rad3 related (‘ATR’) activation is accelerated, on the basis of alternative information about an expression level of cryptochrome may be acquired, therefore, it can be determined that a restoration rate of damaged DNA is high at a time period when the expression level of cryptochrome is high. Accordingly, a time period when a restoration rate of DNA damaged by different causes is high, can be determined. Further, it is possible to estimate a time period when side effects occurring due to using an anticancer drug are minimized, and then, utilize the estimated result in determining the timing of administration of an anticancer drug.

Description

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Claims

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Application Information

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Owner DONG A UNIV RES FOUND FOR IND ACAD COOP
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