The invention discloses a drug for preventing and treating pigeon paramyxovirus type I (PPMV-I). The drug is mainly prepared from the following raw materials in parts by weight: 20-40 parts of honeysuckle, 40-60 parts of scullcap, 50-70 parts of goldthread, 50-80 parts of weeping forsythia, 40-60 parts of dyer woad leaves, 30-50 parts of felwort, 45-60 parts of common andrographis herb, 32-43 parts of wild chrysanthemum flower, 35-52 parts of poria with hostwood, 34-50 parts of agaric, 30-45 parts of liquorice, 10-20 parts of realgar, 5-10 parts of dried ginger, 5-10 parts of herba schizonepetae, 1-5 parts of kudzuvine root, 1-5 parts of akebia stem, 40-50 parts of wheat, 20-30 parts of carthamus fruit, 40-50 parts of sorghum, 4-10 parts of enrofloxacin, 2-5 parts of neomycin, 30-50 parts of vitamin, 13-26 parts of glucose and 20-30 parts of kidney swollen antidote. The drug is prepared through the steps of material selection, mixing, pelleting and drying. According to the invention, drug particles are prepared by mixing traditional Chinese medicines and western medicines; the drug is a result summarized and explored from practices in breeding pigeons for a long time; the drug has a good effect in preventing and treating PPMV-I and is worthy of popularization and application.