Capsule formulation

[0060]The fine powder of a litmus reagent that changes to red in response to acid (blue, Wako Pure Chemical Industries Ltd. high grade), used as an active ingredient, is dispersed or dissolved in 0.2% by weight each of MCT, which is an edible oil (medium chain fatty acid triglyceride, coconad MT (made by Kao Co.) and glycerin, which is a water-based edible additive (made by Kao Co.) (dissolves very readily in water, comparative example). Then, 300 μL each of this solution is loaded into the separated body portion of an acid resistant hard capsule made by Capsugel (DRcaps (trademark), size no. 2, transparent no color). Then, a capsule formulation is prepared by sealing the fitted part of the cap portion and the body portion of the hard capsule using a band sealing solution (see FIG. 1). It should be noted that the band sealing solution is produced based on the information described in International Application PCT / US2013 / 041838 (application date May 20, 2013) (title of invention “AC

[0064]The experiment was carried out with the same conditions used in example 1 (amount of oil, measurement conditions, measurement time, and the like), and the effect on acid resistance when another oil or surfactant is enclosed in the capsule was examined. In this example, the following criteria were determined based on the color of the fine litmus powder dissolved or dispersed in oil enclosed in a capsule.

[0065]“−”: almost all red / unsuitable

[0066]“+”: about half red / passable

[0067]“++”: all blue / excellent

[0068]The results are shown below.

TABLE 1SpecificSubstanceProductManufacturer ResultGravityNameNameNameOil Color(color)(25° C.)Iodine ValueGlycerinGlycerinKao Co.None−1.264NAGlycerinPoem DO-100VRikenNone−1.02NAfatty acid esterVitamin Co., Ltd.SorbitanSO-30VNikkoNone−0.95NAfatty acid esterChemicalsCo., Ltd.Safflower oilSafflowerSummit OilNone++0.92114-150salad oilMill Co. Ltd.Olive oilPharmacopeiaKaneda Co.,None++0.91 70-90olive oilLtd.Soybean oil Soybean oilRikenNone++0.92114-1