Ventriculoamniotic shunt for fetal aqueductal stenosis
a technology of fetal aqueductal stenosis and ventriculoamniotic shunt, which is applied in the direction of medical devices, medical devices, coatings, etc., can solve the problems of severe cns ventriculomegaly, damage to the developing brain, and associated neurologic consequences, so as to prevent the migration of the shunt device
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[0083]Fetal sheep were injected with BioGlue, a biological epoxy of purified bovine albumin and glutaraldehyde, into the cisterna magna at mid-gestation (80-90 days of 145 days gestation). The BioGlue remained within the cisterna magna and therefore, did not interfere with or obscure intraventricular histology. The shut device was placed at varying gestational ages between 110 and 130 days. Shunted brains were compared to non-shunted hydrocephalic controls at term. Using immunocytochemical staining, the hypothesis that neuronal injury in fetal hydrocephalus is secondary to increased intracranial pressure, which leads to tissue ischemia and mechanical axonal shear, was supported.
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