7 results about "Acyl group" patented technology

An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof:

wherein R¹ represents H or methyl, R² and R³ each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

A photosensitive resin composition includes: an alkali-soluble resin; an o-naphthoquinonediazidesulfonic acid ester; a silsesquioxane having at least two thiol groups in a molecule; and a solvent. The silsesquioxane is obtained by subjecting to condensation a silane material which includes a thiol-group-containing silane represented by R^aSi(OR^b)₃. R^a represents a C₁-C₈ organic group that contains a thiol group and that is free from an aromatic group, or an organic group that contains a thiol group and an aromatic group. R^b independently represents hydrogen, a C₁-C₆ alkyl group, a C₁-C₆ acyl group, or a C₆-C₁₅ aromatic group.

The invention belongs to the field of organic synthesis, and discloses a method for synthesizing a naphthopyran-2-ketone compound. The method comprises the following step: in the presence of benzoquinone, palladium acetate, 3-(4-methoxyphenyl) thiopropane-1-sodium sulfonate and a solvent, a phenolic compound and butyl acrylate react to obtain the naphthopyran-2-ketone compound carrying out a reaction. The phenolic compound is selected from one of the following structures as shown in the specification, wherein R1 is selected from hydrogen, halogen, alkoxy and ester group, R3 is selected from hydrogen, alkyl, alkoxy, trifluoromethyl, acyl and naphthyl, and R2 is selected from hydrogen or halogen. The reaction conditions are simple and mild, only one catalyst is needed, the use amount of thecatalyst is small and only needs 10 mol%, the reaction starts from olefin carboxylic ester, and therefore the reaction has higher economical efficiency. The reaction has good universality, is suitablefor substrates with different substituents, and has high yield.

The invention relates to a synthesis method of 2-chloro-1-(2, 2-dimethyl-4H-benzo [1, 3] dioxin-6-yl) ethanone, the method comprises the following steps: (1) carrying out hydroxymethylation on methyl 4-hydroxybenzoate to obtain methyl 4-hydroxy-3-(hydroxymethyl) benzoate; (2) carrying out acetonylidene protection on ortho-dihydroxyl of the 4-hydroxy-3-(hydroxymethyl) methyl benzoate, so as to obtain 2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-carboxylic acid methyl ester; and (3) carrying out chloromethylation on the 2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-carboxylic acid methyl ester, so as to obtain the 2-chloro-1-(2, 2-dimethyl-4H-benzo [d] [1, 3] dioxin-6-yl) ethanone. The synthesis route does not involve a Friedel-Crafts acylation reaction, liquid bromine does not need to be used, the initial raw materials belong to bulk chemicals, the synthesis route is short, the synthesis route is safer and more environmentally friendly, and mass production of the 2-chloro-1-(2, 2-dimethyl-4H-benzo [1, 3] dioxin-6-yl) ethanone is easy to achieve.

The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R⁴⁸ is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Va); and (ii) converting said compound of formula (Va) to a compound of formula (Ia) or (Ic); or (B) (i) treating a compound of formula (IVb), where R⁴⁸ is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Vb); and (ii) converting said compound of formula (Vb) to a compound of formula (Ib) or (Id).