4 results about "Globulin" patented technology

The present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell disease. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-α factor and an exogenous source of nitric oxide.

The invention relates to a method for rapidly detecting human body fatigue by using a protein composition in saliva, and belongs to the technical field of human body fatigue detection. The method comprises: determining the fatigue state of a human body by measuring the content of saliva amylase and immunoglobulin K in saliva; wherein the content of the salivary amylase and the immunoglobulin K is in positive correlation with the fatigue state of a human body. According to the non-invasive fatigue marker detection method, the protein marker composition which has good stability and specificity when the human body is in the fatigue state and has the content positively related to the fatigue degree is used for judging whether the human body is fatigue or not and judging the fatigue degree, and the fatigue degree of the human body can be accurately, simply and rapidly determined; and moreover, human tissues cannot be damaged, and the method has the advantages of noninvasive and painless effects and remarkable social significance.