Compound amoxicillin soluble powder and preparation method thereof
An amoxicillin and soluble technology, which is applied in the field of drug preparation, can solve the problems of low solubility of amoxicillin, affecting amoxicillin, and losing antibacterial activity, etc., to improve stability and solubility, promote solubility, and reduce damage Effect
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[0031] The present invention also provides a preparation method of the compound amoxicillin soluble powder described in the above scheme, comprising the following steps:
[0032] Amoxicillin trihydrate, potassium clavulanate and protective agent are first mixed to obtain the first mixture;
[0033] The first mixture, the pH regulator, the surfactant and the filler are mixed for the second time to obtain the compound amoxicillin soluble powder.
[0034] In the present invention, the first mixing time is preferably 15 to 20 minutes, more preferably 16 to 19 minutes, further preferably 17 to 18 minutes; the second mixing time is preferably 15 to 20 minutes, more preferably 16 to 18 minutes. 19 minutes, more preferably 17-18 minutes. The present invention has no special requirements on the mixing method and mixing equipment, which are methods and equipment well-known to those skilled in the art, subject to being able to mix the materials uniformly.
[0035] In the present invention
Embodiment 1
[0039] A kind of compound recipe amoxicillin soluble powder, by mass percentage, the component is:
[0040]
[0041]
[0042] The compound amoxicillin soluble powder is prepared by the following method: the protective agent carboxymethyl cellulose and polyethylene glycol 6000 are frozen and ultrafinely pulverized, passed through a 1000-mesh sieve, and the sieve is taken to obtain the protective agent micropowder; the amoxicillin The trihydrate, potassium clavulanate, and protective agent micropowder are put into the mixer for the first mixing, mixed for 18 minutes to obtain the first mixture; the first mixture and the remaining materials are mixed for the second time, and mixed for 18 minutes to obtain compound amoxicillin Soluble powder 1000g.
[0043] For the compound amoxicillin soluble powder obtained in the examples, its properties, main components, dissolution, and active ingredient content were detected according to the method in the Ministry of Agriculture "Veterinary
Embodiment 2
[0045] A kind of compound recipe amoxicillin soluble powder, by mass percentage, the component is:
[0046]
[0047] The preparation method and detection method are the same as in Example 1.
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