The invention discloses a preparation method of a capillary open tubular column based on
silicon dioxide
zeolite nanoparticles. The preparation method comprises the following steps: mixing a
silicon source, an alkali source and water according to certain proportion, stirring, clarifying, removing
ethanol through water bath, and performing hydrothermal
crystallization to obtain silicalite-1 silicondioxide
zeolite nanoparticles; dispersing the prepared
silicon dioxide
zeolite nanoparticles into a
solvent, adding into a bare
fused quartz capillary, sealing the two ends of the capillary, and
sintering at high temperature to prepare the capillary open tubular column based on the
silicon dioxide zeolite nanoparticles. A
capillary electrochromatography of the capillary open tubular column basedon the
silicon dioxide zeolite nanoparticles is combined with an amperometric detection
system, separation and analysis of homologous compounds and multiple groups of isomers such as branched chain isomerism, position isomerism and conformation isomerism can be realized. The capillary open tubular column is simple in preparation process, good in separation effect and low in analysis cost; by adoption of an amperometric detection technology, the detection sensitivity of the
capillary electrochromatography technology can be further improved.