The invention discloses a production method of a large-wall-thickness straight-seam submerged-arc-welded pipeline steel plate, comprising the steps of smelting and continuous casting, heating, rolling, cooling, and straightening; in the step of smelting and continuous casting, a casting blank from the continuous casting comprises, by weight, 0.03-0.07% of C, </=0.10% of Si, 1.5-1.7% of Mn, </=0.015% of P, </=0.002% of S, 0.015-0.045% of Als, 0.20-0.30% of Cr, 0.055-0.070% of Nb, 0.010-0.030% of Ti, and the balance of Fe and unavoidable impurities. A large-wall-thickness pipeline steel base product produced via the method has uniform mechanical properties at 0/4, 2/4 and 4/4 along its thickness in directions perpendicular to and parallel to the rolling direction, with small differences in metallographic structure type and grain size; after production, a difference between maximum diameter and minium diameter of end ports of a steel pipe is 0.1-1.2 mm, end roundness deviations of the steel pipe range from 0.5 mm to 4.5 mm, and roundness index is increased by 55-70%. The large-wall-thickness straight-seam submerged-arc-welded pipeline steel plate produced via the method has the advantages such as high uniformity of mechanical properties, and small roundness deviation and high index after subsequent pipe forming.