The invention relates to a ketonic oxime type silicone sealant and a preparation method thereof. The ketonic oxime type silicone sealant comprises the following raw material components in parts by weight: 100 parts of dyhydroxy polysiloxane, 40-80 parts of dimethyl silicon oil, 0.5-2 parts of a component A, 0.5-2 parts of a component B, 15-25 parts of packing, 5-12 parts of a cross-linking agent,0.5-3 parts of a silane coupling agent and 0.05-0.5 part of a catalyst, wherein the component A comprises nanosilver supported by a carrier; the component B comprises a thiazole compound. The ketonicoxime type silicone sealant is not liable to yellowing, good in anti-mold effect, short in surface dry and curing time and convenient to construct.