4 results about "Reaction step" patented technology

The invention discloses a method for preparing erlotinib. The method comprises the following steps: mixing compounds of formula I, formula II and formula III as shown in the specification, and performing a reaction on the three compounds, thereby obtaining erlotinib. The method is short in reaction step, simple and convenient to operate, convenient in quality control, relatively high in yield and relatively low in cost.

The invention discloses a chemical-enzyme method used for synthesis of cinacalcet. The chemical-enzyme method cmprises following steps: under catalyst effect of lipase, racemic 1-(1-naphthyl)ethanol and a fatty acid vinyl ester are subjected to kinetic resolution in a solvent so as to obtain (S)-1-(1-naphthyl) ethanol; under the effect of a catalyst, (S)-1-(1-naphthyl) ethanol and 3-(3-(trifluoromethyl)phenyl)propylamine are subjected to Mitsunobu reaction so as to obtain cinacalcet. According to the chemical-enzyme method, racemic 1-(1-naphthyl)ethanol is taken as an initial raw material, biological enzyme resolution is adopted so as to obtain (S)-1-(1-naphthyl) ethanol, and (S)-1-(1-naphthyl) ethanol and 3-(3-(trifluoromethyl)phenyl)propylamine are subjected to Mitsunobu reaction so asto obtain cinacalcet. Compared with the prior art, the advantages are that: reaction steps are few; operation is simple; no high pressure container is used for hydrogenation reduction; no expensive reducing agent is used; reaction conditions are mild; safety is high; the yield and purity are high; and the purity is as high as 99% or higher.

The invention belongs to a synthesis technology of a surfactant, and relates to a preparation method of a novel amino acid and meglumine surfactant. Specifically, the method comprises the following steps of: sequentially adding glycidyl ester, amino acid or meglumine substances, inorganic alkali and deionized water into a reaction kettle provided with a stirring device, heating to perform a reaction, and cooling to room temperature after the reaction is finished; and pouring reaction liquid into an organic solvent, separating out a solid, carrying out suction filtration while the solid is hot, and drying to obtain a product. According to the preparation method of the novel amino acid and meglumine surfactants,the novel C-N connected amino acid and meglumine surfactants are prepared through one-step reaction of glycidyl ester and amino acid or meglumine, the reaction steps are few, the yield is high, aftertreatment is simple, and good market prospects are achieved.

The invention discloses a synthesis method of vildagliptin, and relates to the technical field of synthesis of pyrrolidine heterocyclic compounds. The synthesis method comprises the following steps: (1) obtaining (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile through acid amine condensation reaction by using (S)-pyrrolidine-2-formonitrile and glyoxylic acid as the raw materials; (2) obtaining 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium through addition reaction of (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile and sodium metabisulfite; (3) obtaining vildagliptin through reductive amination reaction of 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium and 3-amino-1-adamantanol. The synthesis method of vildagliptin is fewer in reaction steps, high in yield, easy in removal of byproducts, simple and convenient to operate, lower in cost and capable of obtaining a product with high chemical purity and optical purity.