Cohesive liquid bolus comprising bioactives

Inactive Publication Date: 2016-05-12
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]These needs are met by the present invention, which provides a novel, nutritionally reinforced, swallow-safe bolus and a method for preparing the same. The bolus of the invention helps to prevent or treat the clinical complications of dysphagia by

Problems solved by technology

Oral pharyngeal dysphagia, on the other hand, is a very serious condition and is generally not treatable with medication.
In addition, radiotherapy and chemotherapy may weaken the muscles and degrade the nerves associated with the physiology and nervous innervation of the swallow reflex.
It is also common for individuals with progressive neuromuscular diseases, such as Parkinson's Disease, to experience increasing difficulty in swallowing initiation.
Dysphagia is not generally diagnosed although the disease has major consequences on patient health and healthcare costs.
As the general awareness of swallowing impairments is low among front-line practitioners, dysphagia often goes undiagnosed and untreated.
Commonly, the inability to properly swallow foods and liquids may be due to food boluses being broken up into smaller fragments, which may enter the airway or leave unwanted residues in the oropharyngeal and/or esophageal tract during the swallowing process (e.g., aspiration).
If enough material enters the lungs, it is possible that the patient may drown on the food/liquid that has built up in the lungs.
Even small volumes of aspirated food may lead to bronchopneumonia infection, and chronic aspiration may lead to bronchiectasis and may cause some cases of asthma.
Individuals who have general pneumonia as the principal diagnosis have a mean 6 day hospital length of stay and incur over $18,000 in costs for hospital care.
It is expected that aspiration pneumonia would carry higher costs for hospital care, based on a mean 8 day length of hospital stay.
In addition, an acute insult such as pneumonia often initiates the downward spiral in health among elderly.
An insult is associated with poor intakes and inactivity, resulting in malnutrition, functional decline, and frailty.
Similar to pneumonia, dehydration is a life-threatening clinical complication of dysphagia.
Dehydration as the principal diagnosis is associated with a mean 4 day length of hospital stay and over $11,000 in costs for hospital care.
Malnutri

Method used

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Examples

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Effect test

Embodiment Construction

[0036]The present invention provides a bolus selected from a cohesive liquid having (i) a shear viscosity of less than about 400 mPas, and (ii) a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20° C.; the bolus comprising: (1) an aqueous solution of at least one food grade biopolymer selected from the group consisting of botanical hydrocolloids, microbial hydrocolloids, animal hydrocolloids, algae hydrocolloids and any combination thereof; and (2) at least one bioactive compound selected from: (a) Anabolic compounds; (b) Anti-catabolic compounds; (c) Cell function or neuromuscular junction stimulating compounds; and (d) Cell energy metabolism stimulating compounds.

Bolus

[0037]As used herein, term “bolus” refers to a physical portion of a food or beverage that can be swallowed by a patient. Said bolus may be in solid, semi-solid or liquid form and may comprise one or more nutrients, foods

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Abstract

This invention relates to a cohesive thin liquid bolus comprising an aqueous solution of at least one food grade biopolymer and at least one bioactive compound, to the use of said cohesive thin liquid bolus for promoting safer swallowing of food boluses in dysphagic patients and to a method for preparing the bolus.

Description

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Claims

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Application Information

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Owner NESTEC SA
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