7 results about "Heterocyclic compound" patented technology

The invention discloses a trivalent copper catalyst and a preparation method thereof and application to hydrochlorination of acetylene. The preparation method of the trivalent copper catalyst comprises the steps that a nitrogen-containing heterocyclic compound and copper salt are added into a trichloromethane solution to mix to obtain a mixed solution A containing a bivalent copper compound; ionicliquid is added into the obtained mixed solution A, and under the action of an oxidant, a mixed solution B containing a trivalent copper compound is obtained; and a porous solid carrier is immersed in the obtained mixed solution B containing the trivalent copper compound for 0.5-5 h, then the treated solid is taken out, and heated and dried under the condition of blue light irradiation, and the trivalent copper catalyst is obtained. The trivalent copper catalyst is used for the reaction of acetylene hydrochlorination to prepare vinyl chloride. The trivalent copper catalyst is prepared by simple operation steps, the stability and activity of the catalyst are improved, the production cost is lowered, and good application prospect is achieved.

The invention provides thiazole heterocyclic compounds, and a preparation method and application thereof. The thiazole heterocyclic compounds have a general structural formula as described in the specification. Results of cell-level experiments show that the thiazole heterocyclic compounds provided by the invention can inhibit proliferation of K562, HL60 and KGla cells. In particular, the compound (compound 4c) in an embodiment 3 can also inhibit proliferation of K562, HL60 and KGla cells under the condition that the concentration of the compound is lower than the concentration of a positive control drug dasatinib. Thus, the thiazole heterocyclic compounds provided by the invention can be used for treating leukemia.

The invention discloses a preparation method for a supported Mo-based oxidation desulfurization catalyst, and belongs to the technical fields of coal processing, petroleum processing and petrochemical processing, and relates to a preparation method for a solid catalyst for oxidative removal of distillate oil and sulphide-containing thiophene aromatic heterocyclic compounds in the chemical materials. The method is characterized by: loading an organic acid on a porous carrier-supported Mo-based oxide catalyst, then drying at a temperature of 70-120 DEG C; heating to the temperature of 100-180 DEG C in the protection of inert gas, and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute; then heating to the temperature of 200-260 DEG C and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute; then heating to the temperature of 300-340 DEG C and holding for 1-5 hours, wherein the heating rate is 1-10 DEG C per minute to prepare the catalyst. The mixture comprising Mo<6+> and low valence state Mo<5+> is loaded on the surface of the catalyst. With the present invention, the oxidation activity and the desulfurization activity of the supported Mo-based catalyst provided by the present invention can be significantly improved, and a wide application prospect in the field of deep desulfurization is provided.

The invention belongs to the technical field of acid bright copper plating additives and relates to a PEG coupled heterocyclic compound and application thereof in acid bright copper plating. The PEG coupled heterocyclic compound can be used as a leveling agent and a grain refiner, more importantly, can increase the solubility of a slightly soluble component in a brightener in a water phase, effectively avoid the precipitation of the slightly soluble component, meanwhile, improve the compatibility of the slightly soluble component with other components in the brightener, maintain the balance among the components, and avoid the problem of proportional imbalance caused by overlarge consumption speed difference or partial precipitation of the components; the PEG coupled heterocyclic compound,a polyether surfactant and a dithionate compound are pre-prepared into the brightener to be applied to acid copper plating; and through the synergistic effect of the three compounds, the stability ofan MN type brightener system is improved, and meanwhile, the current density range is widened on the basis that good leveling performance is ensured.

The invention discloses a synthesis method of vildagliptin, and relates to the technical field of synthesis of pyrrolidine heterocyclic compounds. The synthesis method comprises the following steps: (1) obtaining (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile through acid amine condensation reaction by using (S)-pyrrolidine-2-formonitrile and glyoxylic acid as the raw materials; (2) obtaining 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium through addition reaction of (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile and sodium metabisulfite; (3) obtaining vildagliptin through reductive amination reaction of 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium and 3-amino-1-adamantanol. The synthesis method of vildagliptin is fewer in reaction steps, high in yield, easy in removal of byproducts, simple and convenient to operate, lower in cost and capable of obtaining a product with high chemical purity and optical purity.

Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.