5 results about "Insulin resistance" patented technology

The invention relates to the use of a composition comprising probiotic bacteria that regulate expression of key components involved in diet-induced insulin resistance for ameliorating or preventing diet-induced insulin resistance. The use of the probiotic strain and / or a fraction of said strain and / or metabolite of said strain for the manufacture of a medicament or a food or feed product to ameliorate diet-induced insulin resistance and help to obtain optimal body weight of a mammal is disclosed. Preferably, the composition comprises at least one probiotic Lactobacillus acidophilus strain and / or a fraction of said strain and / or metabolite of said strain for ameliorating or preventing diet-induced insulin resistance, said composition characterized by up-regulating expression of the ANGPTL4 gene encoding for FIAF in the intestine, down-regulating expression of the Elovl6 gene in the intestine as well as down-regulating expression of the SCD1 gene in skeletal muscles of a mammal, and wherein the probiotic strain is selected from the group of strains consisting of Lactobacillus acidophilus strain LA-5 (DSM13241).

The invention relates to an application of cellular repressor of E1A-stimulated gene (CREG) protein, and in particular to an application of the CREG protein or an active fragment thereof in preparingmedicines for preventing and / or treating overweight, obesity, insulin resistance, hyperlipemia and related diseases thereof. The invention also relates to an application of a recombinant vector or recombinant cells of the CREG protein or the active fragment thereof in preventing and / or treating overweight, obesity, insulin resistance, hyperlipemia and related diseases thereof.