14 results about "Metabolite" patented technology

The invention provides novel curcuminoid formulations which have improved aqueous solubility and bioavailability when compared to known curcuminoid dosage forms. Formulations of the invention exhibit an enhanced intestinal absorption of curcuminoids, a slower curcuminoid metabolism and a reduced rate of systemic curcuminoid elimination. Additionally, upon administration in vivo, the formulations described and claimed herein produce a high, sustained level of the curcuminoid metabolite tetrahydrocurcumin. For example, at about eight to about ten hours after oral administration to a human, tetrahydrocurcumin plasma levels of between about 50 ng/mL to about 175 ng/mL are detectable, even when that metabolite is absent from the administered formulation. Novel processes for making curcuminoid formulations which have improved aqueous solubility and oral bioavailability, and methods of treating a wide variety of inflammatory, immune and neurogenerative disorders and cancers, are also provided.

The invention discloses a dual negative pressure adjustable wound negative pressure therapeutic instrument based on a microprocessor core, comprising an internal negative pressure source, an internal negative pressure control unit, an external negative pressure interface, a regulating valve, an external negative pressure control unit, a wound Drainage device, negative pressure detection unit, flow rate and flow rate detection unit and alarm unit; internal negative pressure control unit and external negative pressure control unit respectively control internal negative pressure source and external negative pressure source to generate negative pressure at the wound, wound drainage device The generated lactic acid metabolites are drained, the negative pressure detection unit detects the pressure at the wound, the flow and velocity detection unit detects the drainage volume and drainage speed at the wound, and the detected signal is fed back to the internal negative pressure control unit or external negative pressure control unit , the control unit controls the negative pressure source according to the feedback signal; when the wound causes massive bleeding, the alarm unit sends out an alarm signal. The present invention can use a negative pressure pump or a hospital negative pressure system as a negative pressure source, which can be flexibly selected in practical applications.

Methods, reagents, compositions, and kits for in situ interaction determination (ISID) via interaction-dependent polymerase chain reaction (ID-PCR) are provided herein. ISID technology is useful for rapidly evaluating potential small molecule-target interactions from mixtures in a single solution. ISID is compatible with unpurified targets in biological samples and can be used to evaluate ligand-binding in DNA-encoded chemical libraries in cell lysates. ISID is also useful to screen ligand interactions of proteins or other molecules in their native state, including their native post-translational modifications and any interactions with accessory proteins and metabolites, in ways that better reflect their relevant biological environment. Because ISID is compatible with crude cell lysates, difficult-to-purify, poorly soluble, intrinsically unstable, and aggregation-prone targets may also be compatible with this method, without requiring truncation or other strategies used to promote heterologous expression.

The present invention discloses a novel anti-PD-L1 compound and applications thereof, and a composition containing the novel anti-PD-L1 compound, and provides a substituted biaryl compound representedby a formula I, a pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a stereoisomer, a tautomer or a prodrug thereof. The formula I is defined in the specification.

The invention relates to a combined process for standard-meeting discharge of garbage percolate treatment, which takes a garbage percolate stock solution or a garbage percolate pretreated by an anaerobic regulating reservoir as a treatment object, and comprises the following steps: step one, the garbage percolate to be treated is treated by a multiple microporous carrier reaction bed film-formed with microorganisms to decompose organic substances in the garbage percolate; step two, the oxidation flocculation treatment is performed; and step three, the multistage filtration treatment is performed, the treatment fluid with CODcr less than 100mg/L is drained, and the multistage filtration comprises micro-filtration, fine filtration and reverse osmosis orderly. The process has low treatment cost, simple process, convenient equipment maintenance, strong anti-load capability, strong internal digestion power of metabolites, and small amount of sludge discharge, is suitable for garbage percolates with different concentrations and different discharge requirements, flexibly adjusts a program of process combination according to percolates, combines multiple high-efficiency single technologies, adopts different combination schemes, and ensures that the advantages of the single technology are better played.

The invention discloses a compound preparation capable of effectively improving the disease resistance of aquatic animals and a preparation method thereof. The compound preparation comprises the following components in parts by mass: 55-65 parts of microbial powder, 10-15 parts of astragalus polysaccharide, 10-15 parts of yeast cell walls, 5-10 parts of plant essential oil and 1-5 parts of vitaminB6. The coordination of the components is capable of reforming the intestinal flora structure, changing the proportion of unsaturated fatty acids in metabolic products of intestinal acid-producing bacteria, inhibiting enteric pathogenic bacteria and other harmful substances, restoring intestinal mucous membranes, promoting digestion and absorption of nutrients, simultaneously enabling animal bodies to have enhanced nonspecific immunity, enhanced stress resistance and stronger resistivity to viruses, pathogenic bacteria, parasites and polluted environments, comprehensively improving the utilization ratio of feed and survival rate of the animal bodies, reducing residual feed, purifying excrement and optimizing and normalizing an intensive culture mode.

The invention discloses a synthesizing method of a single-configuration rabeprazole metabolite.According to the method, rabeprazole thioether serves as a starting material, and the rabeprazole metabolite is synthesized through a five-step reaction.The optimal preparation steps and reaction conditions are screened out through a large number of experiments, the whole technological design is reasonable, and the operability is high.According to the obtained single-configuration rabeprazole metabolite, the chemical purity can reach 99% or above, and the chiral purity is larger than 99.5%.The obtained single-configuration rabeprazole metabolite provides a standard substance for metabolic mechanism research of a rabeprazole drug, can be used for exploring the metabolic process of the drug in organisms and has a great application research value in clinical pharmacokinetic research.

The invention relates to a nutrient slow-release biological soil conditioner, which comprises the following main raw materials: a humiccompound, cassava residues, a foam material, a fermentation strain, and water, wherein except the water, in percentage by weight, the soil conditioner comprises 35-45% of the humiccompound, 45-55% of the cassava residues, 5-10% of the foam material, and 1-5% of the fermentation strain, and the water is used for diluting the fermentation strain and a mixed material. The nutrient slow-release biological soil conditioner produced by using the production method disclosed by the invention is taupe particles; and because main carbon sources and nitrogen sources are wrapped with foams formed by the foam material, and through thorough fermentation, the survival time of active microbes in the sources under extreme conditions is long, and metabolic products can be sustainably provided, thereby increasing the activity period of the soil conditioner, and effectively improving the microcirculation of soil.

The invention discloses a detecting method for cholesterol metabolites in brain tissue. The detecting method comprises the steps that firstly, a cryopreserved brain tissue sample is accurately weighed; then a first reagent is added to conduct first-time extraction, a first extracting solution is collected, then a second reagent is added to conduct second-time extraction, a second extracting solution is collected, and the two-time extracting solutions are combined; and finally, after concentrating and volatilizing drying, a third reagent is added to conduct redissolving, and the extracting result is detected through a liquid chromatograph-mass spectrometer.

The invention relates to a construction method of monascus ruber for producing lovastatin in high yield instead of citrinin. The construction method comprises the following steps: (1) constructing ctnR gene knockout plasmid pGKO2-Neo-up-ctnR-dn; (2) constructing ctnR gene knockout strain GN-01[Delta]ctnR; (3) validating the knockout strain GN-01[Delta]ctnR; (4) constructing mOKC gene overexpression plasmid; (5) introducing the mOKC gene overexpression plasmid in the gene knockout strain GN-01[Delta]ctnR to obtain mokC overexpression strain; (6) validating the mokC overexpression strain. According to the invention, the constructed GN-01[Delta]ctnR gene deleted strain without generating citrinin is constructed by validation of metabolites, and the GN-01[Delta]ctnR-mokC overexpression strainhas ability of producing Monacolin K 30% higher than wild strains, up to 267 mg/L.