The invention discloses a CecroPinP1-like
antibacterial peptide and its application, belonging to the technical field of
biochemistry and
molecular biology. The CecroPinP1-like
antimicrobial peptide consists of 21 amino acids, and its
amino acid sequence is shown in SEQ ID NO:1. CecroPinP1-like antibacterial peptides can inhibit
Escherichia coli,
Streptococcus pneumoniae,
Salmonella typhimurium,
Clostridium perfringens type C,
Staphylococcus aureus,
Listeria monocytogenes,
Pasteurella and other
bacteria Compared with
doxycycline hydrochloride,
amoxicillin,
colistin sulfate and other
antibiotics, the
antibacterial effect is relatively better, and compared with CecroPinP1
antimicrobial peptide, it has stronger
antibacterial activity. The
minimum inhibitory concentration (MIC) of the CecroPinP1-like
antimicrobial peptide against
Streptococcus pneumoniae reached 62.5 μg / mL. CecroPinP1-like
antimicrobial peptides have good
thermal stability, can promote the growth of
livestock and poultry, and have good application prospects in the development of antibacterial drugs and
animal husbandry.