Multipurpose photon cold-set gel and preparation method thereof

[0051] To 20L mass concentration of 0.2% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 6L mass concentration of 2% polylactide (intrinsic viscosity is 0.4dl / g) dichloromethane solution, stir for 3 hours, The stirring speed is 350rpm, and the mixture in the reactor is released. Suction filtration, vacuum drying, ready for filling.

[0052] Mix 0.1 part of carbomer, 1 part of polyethylene glycol and 1 part of glycerin, stir evenly, add 50 parts of water for injection, stir, after completely swelling, add 0.5 part of ethyl p-hydroxybenzoate, 0.1 part of triethanolamine, and then Add the remaining water for injection, continue to stir for 1 hour, add 5 parts of PLGA microspheres, continue to stir for 2 hours, and obtain.

[0054] To 10L mass concentration of 0.5% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add mass concentration of 10L5% polylactide (intrinsic viscosity is 1.0dl / g) chloroform solution, stir for 8 hours, stirring speed 500rpm , release the mixture in the reactor. Suction filtration, vacuum drying, ready for filling.

[0055] Mix 5 parts of carbomer, 10 parts of polyethylene glycol and 5 parts of mannitol, stir evenly, add 50 parts of water for injection, stir, after swelling completely, add the remaining water for injection, adjust with hydrochloric acid solution or sodium hydroxide solution When the pH reaches 6.8, after stirring for 1 hour, add 15 parts of PLGA microspheres and continue stirring for 2 hours to obtain the product.

[0057] To 20L mass concentration is 1.0% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 15L mass concentration as 10% polylactide (intrinsic viscosity is 2.0dl / g) ethyl acetate solution, stir 15 hours, The stirring speed is 650rpm, and the mixture in the reaction kettle is released; it is filtered, vacuum-dried, and prepared for filling.

[0058] Mix 1.5 parts of carbomer, 5 parts of polyethylene glycol and 5 parts of glycerin, stir evenly, add 50 parts of water for injection, stir, after completely swelling, add 0.3 parts of ethyl p-hydroxybenzoate, 0.5 parts of triethanolamine, and then Add the remaining water for injection, continue to stir for 1 hour, then add 30 parts of PLGA microspheres, continue to stir for 2 hours to obtain the product.