Preparation process of total phenolic acids of water cress and pharmaceutical formulation using the ingredient as bulk drug and use thereof for treating liver disease
一种药物制剂、原料药的技术,应用在含有效成分的医用配制品、药物组合、植物原材料等方向,能够解决成本高、有效成分损失大、总酚酸得率低等问题
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
experiment example 1
[0011] 1. Anti-tumor experiments in vivo and in vitro
[0012] 1.1 The antitumor effect of cress total phenolic acid (FS)
[0013] Table 1 Anti-tumor experiment of cress total phenolic acid
[0014] sample
[0015] Note: The results showed that the total phenolic acid of cress had inhibitory effects on the above three cancer cells, and it was dose-dependent.
[0016] 1.2 Anti-liver cancer effect of cress total phenolic acid (FS)
[0017] (1) The inhibitory effect of FS 10 and 20 mg / ml on mouse liver cancer 22 (H22): the inhibition rates were 46.8 and 49.1% respectively (P<0.01=
[0018] (2) FS 10 and 20mg / ml are effective against mouse sarcoma 180 (S 180 ) inhibition: the inhibition rates were 44.6, 74.8% (P<0.01)
[0019] 2. Anti-hepatitis B virus (HBV) effect of cress total phenolic acid (FS)
[0020] Table 2 The inhibitory effect of total phenolic acids of cress on HBV-DNA
[0021] experiment
[0022]...
experiment example 2
[0023] Experimental example 2: preparation of cress total phenolic acid raw material
[0024] Grind the dried cress whole herb into a coarse powder, add 10 times the amount of 70% ethanol to heat and reflux for 2 hours, a total of 3 times, combine the extracts, let cool, filter, and then store the extracts at a temperature lower than 60°C Concentrate under reduced pressure to an extract with a specific gravity of 1.15-1.30 (70°C); add hot water 6 times the amount of the crude drug, dissolve in stages, let stand for 24 hours, filter, add the filtrate to 5 times the amount of the crude drug, and have processed On the polyamide column, rinse with water until the effluent is light yellow, elute with 70% alcohol, collect the ethanol eluate until the eluate bears yellow color, concentrate under reduced pressure at a temperature lower than 60°C, and dry in vacuo to obtain Cress total phenolic acid extract.
experiment example 3
[0026] Preparation of capsules
[0027] Cress total phenolic acid raw material 100g, medicinal starch 100g
[0028] Pass the total phenolic acid of cress and medicinal starch through a 100-mesh sieve, mix evenly, and granulate with an appropriate amount of ethanol. Dry at 60°C, granulate, and pack into capsules.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap