Substrate coating

a technology of substrate and coating, applied in the direction of coating, microcapsules, capsule delivery, etc., can solve the problem of process generation of particles, achieve the effect of maximizing biological/pharmaceutical effect, minimizing the amount of pharmaceutical agent and local side effects, and enhancing bioavailability

Active Publication Date: 2020-10-01
PICOSUN OY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a method to coat pharmaceutical agents to regulate their release and modify their pharmacokinetics. This can be useful for applications that require controlled, slow release over time, different release kinetics in different phases, or different compounds released in a controlled fashion. The coating also protects the medicine from harsh conditions in the stomach and enhances bioavailability to minimize side effects and maximize the compound's effect. This method can also improve patient compliance by reducing the number of times the drug must be taken. Additionally, this invention can be used for biocides that need controlled dosage over time in the operating environment.

Problems solved by technology

If both precursor substances / gasses are simultaneously present in gas phase, the process generates particles, which is not desired and in most instances even detrimental for ALD processes.

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0044]The invention, according to one aspect, pertains to a method for coating a vaporizing substrate. In the present context, the expression “vaporizing substrate” refers to the substrate being vaporized. Coating thus occurs during the process of vaporization of said substrate. In the method, a film coating 12 is deposited on at least a portion of a substrate material 10 that undergoes phase transition from essentially liquid phase to gaseous phase (vapour phase), and wherein the substrate comprises a chemical substance that enters- and participates in chemical deposition reaction(s) in gaseous phase (vapour phase).

[0045]The film coating comprises at least one coating layer 121, 122. The coating layers 121, 122 are further referred to as sublayers.

[0046]To avoid confusion, in present disclosure, the terms “gaseous phase” and “gas phase” are used to designate the state of matter of a substance, e.g. vapour. The term “vapour” is used with reference to a gaseous phase (gas phase) of t...

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Abstract

A method and a device for coating a vaporizing substrate are provided, wherein a film coating 12 is deposited on at least a part of a substrate 10 during the time when the substrate undergoes phase transition from essentially liquid phase to gaseous phase. Gaseous species 101 formed upon vaporizing at least the portion of the substrate material, when undergoing chemical deposition reactions in gaseous phase, produce particulate 11 that forms at least one coating layer to produce the film coating 12.

Description

FIELD OF THE INVENTION[0001]The present invention generally relates to substrate processing methods and apparatus. In particular, the invention pertains to a process for coating vaporizing media by chemical deposition methods.BACKGROUND OF THE INVENTION[0002]Chemical deposition methods occurring in vapour phase, such as Chemical Vapor Deposition (CVD) and Atomic Layer Deposition (ALD), are extensively described in the art. ALD technology generally regarded as a subclass of CVD processes has proved an efficient tool for manufacturing high-quality conformal coatings on various substrates.[0003]ALD is based on alternating self-saturative surface reactions, wherein different reactants (precursors) provided as chemical compounds or elements in a nonreactive (inert) gaseous carrier are sequentially pulsed into a reaction space accommodating a substrate. Deposition of a reactant is followed by purging the substrate by inert gas. Conventional ALD cycle proceeds in two half-reactions (pulse ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C23C16/00C23C16/455C23C16/06
CPCC23C16/45525C23C16/06C23C16/003C23C16/45527C23C16/52C23C16/45544A61K9/2813A61K9/2886C23C16/45555A61K9/5089
Inventor PUDAS, MARKOOKSALA, NIKU
Owner PICOSUN OY
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