6 results about "Glycoprotein" patented technology

The invention provides an ELISA (enzyme linked immunosorbent assay) kit for detecting PRRS antibody and application thereof, belonging to the field of biotechnology. The kit comprises an ELISA slat with recombinant GST-GP5 (glutathione transferase-glycoproteins) protein as coating antigen, a PBS (polydiethylene glycol sebacate) solution, a blood serum diluted solution, a rabbit anti-pig enzyme-labelled bi-antibody, a colour-developing substrate, a terminating liquor, PRRS positive blood serum, PRRS negative blood serum and the like. The kit provided by the invention is used for detecting PRRS antibody; after the indexes like specificity, sensitivity, repeatability and the like of a detection method are inspected, the method is used for detecting serum samples; and the detection coincidence rate with the ELISA kit in the prior art is 90%. The kit provided by the invention has the advantages that the operations are convenient, the repeatability is good, and the kit is suitable for being popularized and applied; a reliable measure for fast detecting PRRSV (pig progenitive and respiratory syndrome virus) antibody is supplied clinically.

The present invention relates to trifunctional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) an optionally protected aromatic hydrazine group for the capturing of oxidized receptor-glycopeptides and (iii) an affinity group for the detection, isolation and purification of captured glycopeptides, their methods of production, as well as their use in methods for detecting, identifying and characterizing interactions between ligands and their corresponding glycoprotein target receptors on living cells and in biological fluids.

The invention relates to an oral paclitaxel composite micelle and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Wherein the composite micelle contains two active pharmaceutical ingredients, one is paclitaxel, the other is a p-glycoprotein inhibitor, and an amphiphilic polymer is used as a carrier. The nano-scale composite micelle is prepared by optimizing the proportion of polyethylene glycol in an amphiphilic polymer and the proportion of paclitaxel to a p-glycoprotein inhibitor drug. Compared with the prior art, the polymer micelle prepared by the preparation method provided by the invention has the following advantages: firstly, the solubility of paclitaxel is increased; 2, the bioavailability of the paclitaxel is improved; and 3, the stability is good.

The use of corticotroph-derived glycoprotein hormone (CGH) to induce lipolysis, treat obesity, insulin resistance, and type II diabetes is described.

Methods and compositions for treating a condition involving gastrointestinal symptoms comprising administering to a patient in need of such treatment an effective amount of a P-glycoprotein substrate, wherein the P-glycoprotein substrate is a compound exhibiting an efflux inhibition ratio (EIR) of greater than or equal to 0.4, wherein the P-glycoprotein substrate is administered in a manner to minimize bioavailability.