Intravascular stent comprising biodegradable macromolecular coating
一种高分子涂层、生物降解性的技术,应用在支架领域,能够解决药物释放率低、有效时间短等问题,达到提高释放效率、延长释放时间、良好生物相容性和可降解性的效果
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specific Embodiment 1
[0020] Specific embodiment 1: A polylysine for stent coating, the preparation method is as follows:
[0021] Step 1. Connect the strain to a culture medium for cultivation, and cultivate it at 25-30°C for 40 hours. The medium includes 100 parts by weight of distilled water, 2 parts of glucose, sodium chloride: 0.1 part, chlorine Calcium chloride: 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, and the pH value of the medium is 6.5.
[0022] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate for 48 hours at 25-30°C; the said fermentation medium includes 100 parts by weight of distilled water, 0.2 parts of peptone, and yeast Ointment 0.2 parts, glycerol 0.5 parts, glucose 0.5 parts, and the pH value of the fermentation medium is 6.5.
[0023] Step 3. Centrifuge the fermentation broth for 20 minutes, collect the cells, and heat it in a water bath, then take the supernatant and...
specific Embodiment 2
[0025] Specific embodiment 2: A polylysine for stent coating, the preparation method is as follows:
[0026] Step 1. Connect the strains to a culture medium for cultivation, and cultivate at 25°C for 40 hours. The culture medium includes 100 parts by weight of distilled water, 2 parts of glucose, sodium chloride: 0.1 part, calcium chloride : 0.1 part, ammonium chloride: 0.1 part, magnesium chloride: 0.1 part, the pH value of the medium is 6.5.
[0027] Step 2. Inoculate the above-mentioned culture solution into the fermentation medium according to the inoculation amount of 5%, and cultivate for 48 hours at 25°C; the said fermentation medium includes: 100 parts by weight of distilled water, 0.2 parts of peptone, and 0.2 parts of yeast extract. The pH value of the fermentation medium is 6.5.
[0028] Step 3. Centrifuge the fermentation broth for 20 minutes, collect the cells, and heat it in a water bath, then take the supernatant and drain the water to prepare polylysine;
[0029] Step...
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