6 results about "Drug carrier" patented technology

The invention provides a polyethylene glycol-polyamide-amine-polyamino acid linear-dendritic block polymer with a structure shown as a formula I, II, III or IV. The polyethylene glycol in the block polymer can be used for improving the biocompatibility of the block polymer and prolonging the circulation time of the block polymer in the blood, and a polyamino acid block can be used for ensuring the favorable degradation performance of a product and can be discharged in vitro after being degraded in vivo. The block polymer provided by the invention is simple in preparation method and safe and nontoxic in product. The block polymer is used as a carrier and assembled in water to form nanoparticles, and a model drug adriamycin is carried, so that drug-carried nanoparticles are obtained, and the drug-carried nanoparticles have a certain controlled-release function and can be used for effectively inhibiting the proliferation of cancer cells in cell experiments. Therefore, the block polymer has the potential application as a nano-drug carrier.

The invention provides a preparation method for polyvinyl alcohol/silicon dioxide composite microspheres and belongs to a preparation method for a composite microsphere material. Polyvinyl alcohol and tetraethyl orthosilicate are employed as raw materials, and polyvinyl alcohol/silicon dioxide (PVA/SiO2) composite microspheres are prepared in a water-in-oil system without any surfactants. Tetraethyl orthosilicate is hydrolyzed fully in a PVA solution in an acidic condition, and uniform PVA/SiO2 composite sol is formed; the sol is subjected to dispersion and crosslinking in a water-in-oil system without surfactants, and finally PVA/SiO2 composite microspheres are obtained. The technology is simple, the repeatability is good, energy consumption is low and the cost is low. Surfactant residual and agglomeration of nano inorganic particles in the process of preparing composite microspheres through a traditional emulsification method are avoided. The microspheres are advantaged by regular sphere, high dispersibility and uniform microstructure, and can be used as a drug carrier, an injection-type bone tissue repairing material or a heavy metal ion adsorption material.

The invention provides an exosome nano drug loading system modified by superparamagnetic nano-iron. The exosome nano drug loading system comprises an exosome for loading an insulin secretion-promotingdrug and superparamagnetic nano-iron, wherein the superparamagnetic nano-iron is distributed on the surface of the exosome and is connected to the exosome through the combination of transferrin and atransferrin receptor on the surface of the exosome, and the superparamagnetic nano-iron enables the exosome carrier to have targeting ability and blood glucose responsiveness under the action of an external magnetic field. According to the invention, the exosome loads a diabetes medicine, an exosome nano-carrier is prepared, superparamagnetic nano-iron SPION is adopted as an exosome target head to achieve targeted delivery, pancreatic tissue is targeted through an external magnetic field, the drug carrier is endowed with blood glucose responsiveness, and a nano drug delivery system capable ofeffectively prolonging the in-vivo half-life period of diabetes drugs and having blood glucose response is obtained.

The invention discloses a cationic macromolecular proteolipid gene medicine carrier, a preparation method and an application, wherein the cationic macromolecular proteolipid gene medicine carrier is a macromolecular transferrin liposome prepared by transferrin-long-chain alkyl quaternary ammonium salt and a lipid ingredient in a mass ratio of (0.05 to 20): 1. The result of a gene transfection experiment indicates that the gene transfection efficiency of the macromolecular transferrin liposome in 293T cells, NIH-3T3 cells, liver cancer Huh-7 cells, SMMC-7721 cells, lung cancer A549 cells is equivalent to the gene transfection efficiency of a positive control, namely a cationic liposome Lipofectamine TM2000. The system of the cationic macromolecular proteolipid gene medicine carrier is good in biocompatibility, low in cytotoxicity, and capable of being used as an excellent non-viral gene medicine delivery carrier.