The invention relates to the technical field of traditional Chinese medicines, in particular to a medicinal wine for lowering blood pressure, which is brewed from the following medicinal materials and rice wine in parts by mass: 20-30 parts of Gastrodia elata from Guizhou, 15-25 parts of Danshen, and 15-25 parts of Ligustrum lucidum , 15-25 parts of Daqingye, 15-25 parts of chrysanthemum, 10-16 parts of pinellia, 15-20 parts of dandelion, 10-16 parts of Polygonum multiflorum, 15-20 parts of angelica, 15-20 parts of longan, 10- 16 parts, 10-18 parts of honeysuckle, 10-14 parts of stone string lotus, 10-14 parts of Eucommia, 8-12 parts of knotweed, 5-9 parts of rose, 8-12 parts of jujube seed, 8-12 parts of sky fruit, Albizia juniper skin 5-9 parts, safflower 5-9 parts, kudzu root 3-7 parts, rice wine 200-250 parts. The antihypertensive medicated wine of the present invention can treat high blood pressure and alleviate the headache symptoms of hypertensive patients; it can not only reduce and stabilize blood pressure but also prevent stroke caused by cerebrovascular blockage and Alzheimer's disease; at the same time, it can improve blood circulation and prevent blood vessel pain. Blockage can help prevent heart disease and stroke; long-term use can help hypertensive patients adjust their body functions, and can reduce or even stop other antihypertensive drugs.