The invention discloses a preparation method of berberine hydrochloride tablets, which comprises the following steps: 1, crushing rhizoma coptidis to a particle size of 100-mesh, adding dietary alkaliwith an amount being 1-3% of the rhizoma coptidis, uniformly mixing, cooking with steam for 4-6 h, and cooling to obtain cooked rhizoma coptidis powder; step 2: placing 10 parts by mass of berberinehydrochloride, 30 to 40 parts by mass of cooked rhizoma coptidis powder, 20 to 30 parts by mass of 70% ethanol, 2-3 parts by mass of beewax and 2-3 parts by mass of sodium carboxymethyl starch in an efficient wet type granulator, starting stirring at a low speed for 5 min, then starting stirring at a high speed for 5 min, after stirring is conducted for 10 min, starting a grain-sized dicing motor,and after 5 min, discharging in a clean, dry and dust-free stainless steel disc to obtain wet granules; and 3, putting the wet granules obtained in the step 2 into a drying vehicle, putting the drying vehicle into a drying room, drying, and tabletting to obtain the berberine hydrochloride tablet preparation.