Purification method of teicoplanin
一种纯化方法、替考拉宁的技术,应用在替考拉宁的纯化领域,能够解决影响生产环境和人员健康、分离纯化效果差、操作难度大等问题,达到避开有机溶剂残留、外观颜色改观、保护环境的效果
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[0026] (1) 100L of teicoplanin fermented liquid is adjusted pH to be 9~11 with 4% sodium hydroxide, carries out assay, and content is 1257mg / L, filters through the ceramic membrane of 50nm, and filtration temperature is less than 25 ℃, and top water amount is 300L, the final obtained ceramic membrane filtrate was 376L, the measured content was 330mg / L, and 124.08g of teicoplanin was recovered with a yield of 98.71%.
[0027] (2) With the ceramic membrane filtrate obtained in step (1), the pH is adjusted to be 6.5 to 7.5 with 5% hydrochloric acid, adsorbed by the macroporous adsorption resin FX-06, and the resin is washed with water until the water that flows out is colorless, and then used 0.1mol of ammonia water was analyzed at a flow rate of 2BV / hr to obtain 21.5L of analytical solution; the pH was adjusted to 5.0-6.0, the content was determined to be 4963mg / L, and 106.7g of teicoplanin was recovered with a yield of 85.99%. The analytical solution was analyzed by HPLC, and t...
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