Florfenicol/colistin sulfate soluble powder and preparation method thereof

[0016] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 5%, colistin sulfate 2%, borax 2%, citric acid 30%, potassium bicarbonate 2%, poly Vinylpyrrolidone (k30) 7.5%, poloxamer 188 5%, and the balance is anhydrous glucose.

[0017] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0018] (1) Take absolute ethanol twice the mass of polyvinylpyrrolidone (k30), add absolute ethanol into polyvinylpyrrolidone (k30) under stirring, after the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0019] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 80°C for 15 minutes, then crush it and pass it through a 60-mes...

[0022] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 20%, colistin sulfate 20%, borax 0.5%, citric acid 5%, potassium bicarbonate 0.1%, poly Vinylpyrrolidone (k30) 30%, poloxamer 188 1%, and the balance is anhydrous glucose.

[0023] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0024] (1) Take absolute ethanol that is 1.8 times the mass of polyvinylpyrrolidone (k30), and add absolute ethanol to polyvinylpyrrolidone (k30) under stirring. After the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0025] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 105°C for 30 minutes, then crush it and pass ...

[0028] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 10%, colistin sulfate 10%, borax 1%, citric acid 15%, potassium bicarbonate 1%, poly Vinylpyrrolidone (k30) 20%, poloxamer 188 3%, and the balance is anhydrous glucose.

[0029] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0030] (1) Take absolute ethanol that is 3.6 times the mass of polyvinylpyrrolidone (k30), and add absolute ethanol to polyvinylpyrrolidone (k30) under stirring. After the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0031] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 90°C for 20 minutes, then crush it and pass it t...