The invention discloses a
florfenicol /
colistin sulfate soluble
powder which is composed of the following components in percentage by weight: 5-20% of
florfenicol, 2-20% of
colistin sulfate, 0.5-2% of
borax, 5-30% of
citric acid, 0.1-2% of
potassium bicarbonate, 7.5-30% of
polyvinylpyrrolidone, 1-5% of
poloxamer 188 and the balance of
anhydrous glucose. The invention also discloses a preparation method of the soluble
powder, which comprises the following steps: dissolving the
polyvinylpyrrolidone in
anhydrous ethanol, adding the
florfenicol,
citric acid,
borax,
potassium bicarbonate and
poloxamer 188, evenly mixing, recovering the
ethanol,
drying, pulverizing, adding the
colistin sulfate and
anhydrous glucose, and evenly mixing. The soluble
powder ensures that the two reagents simultaneously enter the
organism and better display the synergic
antibacterial action; the method is simple and convenient to operate, and enhances the production efficiency; and the
anhydrous ethanol is recovered, so the method protects the environment and is suitable for industrial production.