The invention discloses a liver-clearing and vision-improving preparation for treating nyctalopia. The liver-clearing and vision-improving preparation is mainly prepared from, by mass, 9 parts to 14 parts of indigofera stachyodes, 7 parts to 13 parts of celastrus gemmatus loes, 8 parts to 16 parts of centella, 6 parts to 13 parts of ligularia stenocephala, 9 parts to 12 parts of mulberry leaf distillate, 6 parts to 10 parts of vespertilionum faeces, 11 parts to 17 parts of perilla leaves, 9 parts to 13 parts of balanophora mutinoides, 7 parts to 15 parts of ardisia maculosa, 8 parts to 14 parts of lemon leaves, 7 parts to 12 parts of joint vetch, 6 parts to 9 parts of tribulus terrestris, 8 parts to 13 parts of mentha spicata, 9 parts to 15 parts of berchemia kulingensis and 7 parts to 14 parts of endives. According to the liver-clearing and vision-improving preparation, the adopted medicinal materials are supplemented with each other, and the liver-clearing and vision-improving preparation has the effects of dispelling wind and heat, clearing the liver and improving vision, and has the remarkable curative effect on treating the nyctalopia; more attention is paid to caring of eyes on the treatment base, pathogenetic times and the pathogenetic probability are reduced, and the liver-clearing and vision-improving preparation is safe and reliable.