3 results about "Zinc nitrate" patented technology

The invention discloses porous zinc oxide nano powder and a preparation method thereof. The method comprises the following steps: firstly, zinc nitrate hexahydrate is dissolved in anhydrous ethanol or deionized water, added with PEG 400 under the condition of magnetic stirring and uniformly mixed; secondly, ammonium bicarbonate is dissolved in the deionized water or the anhydrous ethanol; thirdly, the mol ratio of the zinc nitrate to the ammonium bicarbonate is 1 to 2.5, and a zinc nitrate ethanol solution or a zinc nitrate water solution is dripped into the deionized water and/or an anhydrous ethanol solution of the ammonium bicarbonate, and then precursor is obtained; fourthly, the precursor is washed by an ammonium bicarbonate water solution after centrifugal separation, washed by the anhydrous ethanol, dried, added with n-butylalcohol, uniformly dispersed and then refluxed for 1 to 2 hours at a temperature of between 115 and 120 DEG C, the n-butylalcohol is recovered by vacuum distillation, and the porous zinc oxide nano powder is prepared by utilization of afterheat to dry solid by distillation. The particle diameter of the porous zinc oxide nano powder is between 10 and 250 nanometers; the inside of a nano particle has a porous structure; and the aperture of an inner hole of the particle is between 5 and 120 nanometers.

The invention discloses a preparation method of zif-8 nanosphere loaded SERS coded gold nanoparticles for intracellular photothermal therapy. The preparation method comprises the following specific steps: (1) reacting chloroauric acid with trisodium citrate to generate 13nm gold nanoparticles; (2) labeling gold nanoparticles by using a Raman reporter DTTC, and adding sulfydryl-containing polyethylene glycol to stabilize the gold nanoparticles; (3) adding polyethylene glycol with a sulfydryl group at one end and a carboxyl group at the other end into (2), modifying the surfaces of the gold nanoparticles with a large amount of carboxyl groups, adding adriamycin and an activating agent, and reacting the materials for 24 hours to obtain drug-loaded gold nanoparticles; and (4) dispersing the drug-loaded gold nanoparticles in the step (3) into zinc nitrate and ligand dimethylimidazole, and reacting the materials to obtain the zif-8 nanosphere loaded SERS coded gold nanoparticles. The SERS coded drug-loaded nanoparticles prepared by the invention can be used for inhibiting cell transfer and intracellular photothermal therapy, and the drug is loaded on the surfaces of the gold nanoparticles to realize internalization of the drug and kill cancer cells to the maximum extent.