Method for preparing medical polylactic acid melt-spun fiber porous ordered scaffold

[0044] PLA slices with a molecular weight of 170,000 were prepared by melt spinning into PLA melt-spun fibers with an average diameter of 12.41 μm, and a YG086 skein length measuring instrument was used to wind parallel aggregates at a speed of 300 r / min. The circumference is 1000mm, the width is 3.5cm, and the initial tension is 100cN, and PLA ordered fiber bundles are obtained. Weigh 0.5g of PLGA and dissolve it in 10mL of tetrahydrofuran (volume concentration: 5%), stir until completely dissolved to form a uniform PLGA / tetrahydrofuran solution. Brush the PLGA / tetrahydrofuran solution evenly on the front and back of the PLA ordered fiber bundle twice, and then put it in the fume hood for 24 hours to completely volatilize the tetrahydrofuran. After it is completely volatilized, place it in a vacuum desiccator, and dry it at 45°C for 24 hours to obtain a PLGA bonded PLA fiber porous ordered scaffold (see figure 1 , figure 2 ). The pore diameter of the scaffold is 3.65±2.54...

[0046] PLA slices with a molecular weight of 170,000 were prepared by melt spinning into PLA melt-spun fibers with an average diameter of 12.41 μm, and a YG086 skein length measuring instrument was used to wind parallel aggregates at a speed of 300 r / min. The circumference is 1000mm, the width is 3.5cm, and the initial tension is 100cN, and PLA ordered fiber bundles are obtained. Weigh 0.5g of PGA and dissolve it in 10mL of tetrahydrofuran (5% volume concentration), stir until completely dissolved to form a uniform PGA / tetrahydrofuran solution. Brush the PGA / tetrahydrofuran solution evenly on the front and back of the ordered PLA fiber bundle twice, and then put it in the fume hood for 24 hours to completely volatilize the tetrahydrofuran. After it volatilized completely, put it in a vacuum desiccator, and dry it at 45°C for 24 hours to obtain a PGA-bonded PLA fiber porous and ordered scaffold (see image 3 , Figure 4 ). The pore diameter of the scaffold is 3.15±1.47 μm, a...

[0048] PLA slices with a molecular weight of 170,000 were prepared by melt spinning into PLA melt-spun fibers with an average diameter of 12.41 μm, and a YG086 skein length measuring instrument was used to wind parallel aggregates at a speed of 300 r / min. The circumference is 1000mm, the width is 3.5cm, and the initial tension is 100cN, and PLA ordered fiber bundles are obtained. Weigh 0.5g of PCL and dissolve it in 10mL of tetrahydrofuran (5% volume concentration), stir until completely dissolved to form a uniform PCL / tetrahydrofuran solution. Brush the PCL / tetrahydrofuran solution evenly on the front and back of the PLA ordered fiber bundle twice, and then put it in the fume hood for 24 hours to completely volatilize the tetrahydrofuran. After it is completely volatilized, place it in a vacuum desiccator and dry it at 45°C for 24 hours to obtain a PCL-bonded PLA fiber porous and ordered scaffold (see Figure 5 , Figure 6 ). The pore diameter of the scaffold is 5.89±3.04 ...