The invention discloses a low-complexity space-frequency adaptive anti-interference channel equalization method, and the method comprises the steps: partitioning data at a transmitting end, and addingUW to the tail of each data block; then, enabling the sending signal to arrive at a receiving end and subjecting to timing synchronization preprocessing, and intercepting a received pilot frequency;and respectively performing DFT (Discrete Fourier Transform) on the receiving pilot frequency of each path of antenna to a frequency domain; carrying out sub-band segmentation on the received pilot frequency in a frequency domain, and calculating an optimal time domain adaptive weight of each sub-band; partitioning received data, performing DFT (Discrete Fourier Transform) to a frequency domain, performing sub-band segmentation by using the same method, solving an adaptive weight of each sub-band, performing sub-band space-frequency equalization and combination on a received data block on eachantenna by a receiving end, converting the data block to a time domain, and performing UW (Unscented Wavelength) removal operation. The method is effective in sight distance and non-sight-distance environments in a wireless communication system, has a certain inhibition capability on multipath self-interference and external interference, and effectively improves the survivability of a communication link in a complex electromagnetic environment.