The invention provides a carbon dioxide-slickwater intermittent mixed-fracturing design method. The carbon dioxide-slickwater intermittent mixed-fracturing design method comprises the following stepsthat 1, at a first injection stage, a first slickwater fracturing fluid is injected into a target reservoir; 2, at a second injection stage, a liquid carbon dioxide fracturing fluid is injected into the target reservoir; 3, at a third stage, a second slickwater fracturing fluid is injected into the target reservoir; 4, at a fourth injection stage, the liquid carbon dioxide fracturing fluid is injected into the target reservoir; 5, after the fourth injection stage finishes, well soaking is performed; 6, at a fifth injection stage, the second slickwater fracturing fluid is injected into the target reservoir; 7, at a sixth injection stage, the first slickwater fracturing fluid is injected into the target reservoir, wherein the second slickwater fracturing fluid is prepared from the first slickwater fracturing fluid and a supporting agent. By adopting the method, fracturing fluids of different properties are injected at different stages, the chemical and physical properties of carbon dioxide are reasonably utilized, and the purposes of improving hydraulic fracturing complexity, the reverse discharging rate of the fracturing fluids and oil gas yield are achieved.